SCHEMBL8162245

SCHEMBL8162245

CCOC(=O)C[C@@]1(N)CCCN1C(=O)OCc1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8172630 1.00 CYP2C19 (0.44) CYP2C19SMN1; SMN2
SCHEMBL15937151 0.80
SCHEMBL31722609 0.79 MEN1 (0.52) CYP2C19SMN1; SMN2
Hydrochloric Acid SCHEMBL7581386 0.78 SMN1; SMN2 (0.51) CYP2C19SMN1; SMN2
SCHEMBL6623030 0.78 SYK (0.42)
SCHEMBL28782028 0.77 CHRM1 (0.42)
SCHEMBL978529 0.77 SMN1; SMN2 (0.47) CYP2C19SMN1; SMN2
SCHEMBL14682355 0.77
SCHEMBL14685068 0.77 OPRM1 (0.51)
SCHEMBL3723554 0.77 SMN1; SMN2 (0.46) CYP2C19SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6057457-A ENZYME INHIBITORS FOR PROTEASE OR ENZYMES OF HYDROLYSIS GLAXO WELLCOME INC. (US) 2000-05-02 US disclosed