Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | HINT1 | P49773 | 4/20 | 0.59 |
| ▸ | NT5E | P21589 | 2/20 | 0.59 |
| ▸ | GSK3A | P49840 | 2/20 | 0.56 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.56 |
| ▸ | PNP | P00491 | 2/20 | 0.56 |
| ▸ | TGM2 | P21980 | 1/20 | 0.55 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.54 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.53 |
| ▸ | PDE2A | O00408 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1737326 | 1.00 | HPGD (0.62) | HPGDHINT1NT5EGSK3ARPS6KA3 | |
| SCHEMBL1737325 | 1.00 | HPGD (0.62) | HPGDHINT1NT5EGSK3ARPS6KA3 | |
| SCHEMBL6748870 | 1.00 | HPGD (0.62) | HPGDHINT1NT5EGSK3ARPS6KA3 | |
| SCHEMBL1737322 | 1.00 | HPGD (0.62) | HPGDHINT1NT5EGSK3ARPS6KA3 | |
| SCHEMBL20434874 | 1.00 | HPGD (0.62) | HPGDHINT1NT5EGSK3ARPS6KA3 | |
| SCHEMBL25381419 | 1.00 | HPGD (0.62) | HPGDHINT1NT5EGSK3ARPS6KA3 | |
| F-Arag SCHEMBL35286 | 0.92 | PDE2A (0.64) | HPGDHINT1NT5EGSK3ARPS6KA3 | |
| F-Arag SCHEMBL20581034 | 0.92 | PDE2A (0.64) | HPGDHINT1NT5EGSK3ARPS6KA3 | |
| F-Arag SCHEMBL21625251 | 0.92 | PDE2A (0.64) | HPGDHINT1NT5EGSK3ARPS6KA3 | |
| F-Arag SCHEMBL16656455 | 0.92 | PDE2A (0.64) | HPGDHINT1NT5EGSK3ARPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2399588-A1 | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase | Merck Sharp & Dohme Corp. (US) | 2011-12-28 | — | — | EP | disclosed |
| EP-2360166-A1 | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase | Merck Sharp & Dohme Corp. (US) | 2011-08-24 | — | — | EP | disclosed |
| US-6110901-A | 3'-DEOXYRIBOCYTOSINE, 3'-DEOXYRIBOURACIL, AND/OR 3'-DEOXYRIBOGUANINE | AMERICAN CYANAMID COMPANY (US) | 2000-08-29 | — | — | US | disclosed |