Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.85 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.59 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | FDPS | P14324 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL8168590 | 1.00 | SIGMAR1 (0.85) | SIGMAR1TAAR1ALOX5MAPTRXFP1 | |
| Acetic Acid SCHEMBL8162839 | 0.95 | SIGMAR1 (0.82) | SIGMAR1TAAR1ALOX5MAPTRXFP1 | |
| Acetic Acid SCHEMBL8156302 | 0.95 | SIGMAR1 (0.82) | SIGMAR1TAAR1ALOX5MAPTRXFP1 | |
| Acetic Acid SCHEMBL8163177 | 0.93 | SIGMAR1 (0.79) | SIGMAR1TAAR1ALOX5MAPTRXFP1 | |
| SCHEMBL8079373 | 0.92 | SIGMAR1 (1.00) | SIGMAR1TAAR1KCNH2 | |
| SCHEMBL10726207 | 0.92 | SIGMAR1 (1.00) | SIGMAR1TAAR1KCNH2 | |
| SCHEMBL2117266 | 0.92 | SIGMAR1 (1.00) | SIGMAR1TAAR1KCNH2 | |
| SCHEMBL22442307 | 0.92 | SIGMAR1 (1.00) | SIGMAR1TAAR1KCNH2 | |
| SCHEMBL5721858 | 0.92 | SIGMAR1 (1.00) | SIGMAR1TAAR1KCNH2 | |
| SCHEMBL9670745 | 0.92 | SIGMAR1 (1.00) | SIGMAR1TAAR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6090855-A | WOOD PRESERVATIVE SYSTEM | LONZA, INC. (US) | 2000-07-18 | — | — | US | disclosed |
| US-5523487-A | REACTING A DIALKYLDIMETHYLAMMONIUM CHLORIDE WITH A METAL HYDROXIDE IN AN ALCOHOL SOLVENT TO OBTAIN THE HYDROXIDE SALT FOLLOWED BY REACTING WITH CARBON DIOXIDE | LONZA, INC. (US) | 1996-06-04 | — | — | US | disclosed |
| US-5438034-A | Nonleaching wood preservatives; microbiocides; cationic surfactants | LONZA, INC. (US) | 1995-08-01 | — | — | US | disclosed |