Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 3/20 | 0.46 |
| ▸ | RXRB | P28702 | 2/20 | 0.46 |
| ▸ | RXRG | P48443 | 2/20 | 0.46 |
| ▸ | RARB | P10826 | 1/20 | 0.46 |
| ▸ | RARG | P13631 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 5/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8165526 | 0.88 | RXRA (0.48) | RXRARXRBRXRGTSHRTDP1 | |
| SCHEMBL8165760 | 0.84 | CYP26B1 (0.45) | CYP26A1RXRARXRBRXRGTSHR | |
| SCHEMBL8165521 | 0.83 | TSHR (0.43) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL8166267 | 0.81 | RARB (0.62) | CYP26A1RXRARXRBRXRGRARB | |
| SCHEMBL17911601 | 0.78 | CYP26A1 (0.55) | CYP26A1RXRARXRBRXRGRARB | |
| SCHEMBL29567408 | 0.78 | CYP26A1 (0.55) | CYP26A1RXRARXRBRXRGRARB | |
| SCHEMBL8170066 | 0.77 | RXRA (0.48) | CYP26A1RXRARXRBRXRGTSHR | |
| SCHEMBL17911584 | 0.75 | CYP26A1 (0.67) | CYP26A1RXRARXRBRXRGRARB | |
| SCHEMBL29567511 | 0.75 | CYP26A1 (0.67) | CYP26A1RXRARXRBRXRGRARB | |
| SCHEMBL27593647 | 0.75 | TSHR (0.59) | TSHRTDP1L3MBTL1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6156750-A | Bioactive bicyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2000-12-05 | — | — | US | disclosed |
| US-5985928-A | HUMAN OR VETERINARY MEDICINE FOR EXAMPLE DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1999-11-16 | — | — | US | disclosed |
| US-5763487-A | SKIN DISORDERS, CARDIOVASCULAR DISORDERS AND COSMETICS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-06-09 | — | — | US | disclosed |
| EP-0722928-B1 | Bicyclic-aromatic compounds with strong biologic activity, pharmaceutical and cosmetic compositions containing them and uses thereof | CIRD GALDERMA (FR) | 1997-08-06 | — | — | EP | disclosed |
| EP-0722928-A1 | Bicyclic-aromatic compounds with strong biologic activity, pharmaceutical and cosmetic compositions containing them and uses thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) | 1996-07-24 | — | — | EP | disclosed |