Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OSBP | P22059 | 4/20 | 0.42 |
| ▸ | RORC | P51449 | 3/20 | 0.42 |
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | OSBP2 | Q969R2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | POLA1 | P09884 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | NPC1L1 | Q9UHC9 | 3/20 | 0.36 |
| ▸ | GBA1 | P04062 | 2/20 | 0.36 |
| ▸ | UGCG | Q16739 | 2/20 | 0.36 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.36 |
| ▸ | CRYAB | P02511 | 1/20 | 0.36 |
| ▸ | HMGCR | P04035 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGAV | P06756 | 1/20 | 0.36 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8181517 | 0.85 | OSBP (0.42) | OSBPRORCCYP46A1USP2OSBP2 | |
| SCHEMBL8174627 | 0.84 | OSBP (0.47) | OSBPRORCCYP46A1USP2OSBP2 | |
| SCHEMBL8174993 | 0.80 | CYP46A1 (0.50) | OSBPRORCCYP46A1USP2OSBP2 | |
| SCHEMBL8916630 | 0.72 | POLA1 (0.47) | OSBPRORCCYP46A1USP2OSBP2 | |
| SCHEMBL8915187 | 0.72 | POLA1 (0.42) | OSBPRORCCYP46A1USP2OSBP2 | |
| SCHEMBL7876329 | 0.71 | OSBP (0.59) | OSBPRORCCYP46A1USP2OSBP2 | |
| SCHEMBL4432535 | 0.71 | OSBP (0.60) | OSBPRORCCYP46A1USP2OSBP2 | |
| SCHEMBL8913664 | 0.71 | POLA1 (0.51) | OSBPRORCCYP46A1USP2OSBP2 | |
| SCHEMBL7876330 | 0.71 | POLA1 (0.59) | OSBPRORCCYP46A1USP2OSBP2 | |
| SCHEMBL8913660 | 0.70 | POLA1 (0.50) | OSBPRORCCYP46A1USP2OSBP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6132957-A | CONTACTING A 9-SUBSTITUTED ADENINE WITH A CELL EXTRACT CONTAINING ADENYLATE CYCLASE ACTIVITY, DETECTING THE AMOUNT OF INHIBITION, AND CORRELATING WITH TEST STANDARD OR CONTROL; NOVEL THERAPIES FOR CARDIOVASCULAR DISORDERS | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | 2000-10-17 | — | — | US | disclosed |
| US-5795756-A | Method and compounds for the inhibition of adenylyl cyclase | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK | 1998-08-18 | — | — | US | disclosed |