Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | ENPP2 | Q13822 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1653094 | 0.90 | HTT (0.69) | HTTSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL4063564 | 0.83 | SMN1; SMN2 (0.68) | HTTSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL15732565 | 0.82 | MAPT (0.51) | MAPT | |
| SCHEMBL8174663 | 0.80 | SMN1; SMN2 (0.56) | HTTSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL5241453 | 0.80 | HTT (0.58) | HTTSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL29101231 | 0.80 | SMN1; SMN2 (0.74) | HTTSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL11391276 | 0.80 | HTT (0.60) | HTTSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL11391233 | 0.79 | HTT (0.71) | HTTSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL895978 | 0.78 | HTT (0.77) | HTTSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL2712060 | 0.77 | SMN1; SMN2 (0.77) | HTTSMN1; SMN2NPC1RAB9ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6090825-A | Oxazole derivatives as antagonists of alpha 1C andrenergic receptors | GLAXO WELLCOME INC. (US) | 2000-07-18 | — | — | US | disclosed |
| EP-0793658-A1 | OXAZOLE DERIVATIVES AS ANTAGONISTS OF ALPHA-1C ADRENERGIC RECEPTORS | GLAXO WELLCOME INC. (US) | 1997-09-10 | — | — | EP | disclosed |
| WO-1996016049-A1 | OXAZOLE DERIVATIVES AS ANTAGONISTS OF α-1C ADRENERGIC RECEPTORS | GLAXO WELLCOME INC. (US) | 1996-05-30 | — | — | WO | disclosed |