Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.74 |
| ▸ | NPC1 | O15118 | 2/20 | 0.74 |
| ▸ | RAB9A | P51151 | 2/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MMP1 | P03956 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | MMP3 | P08254 | 1/20 | 0.49 |
| ▸ | MMP7 | P09237 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6473595 | 0.93 | HTT (0.67) | HTTSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL11394508 | 0.88 | HTT (0.74) | HTTSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL5141182 | 0.88 | HTT (0.60) | HTTSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL14313090 | 0.86 | HTT (0.59) | HTTSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL5115243 | 0.86 | HTT (0.59) | HTTSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL5077234 | 0.86 | HTT (0.59) | HTTSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL29101231 | 0.85 | SMN1; SMN2 (0.74) | HTTSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL23243031 | 0.85 | SMN1; SMN2 (0.73) | HTTSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL3533651 | 0.85 | SMN1; SMN2 (0.77) | HTTSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL2712060 | 0.85 | SMN1; SMN2 (0.77) | HTTSMN1; SMN2NPC1RAB9ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560978-B1 | INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS | MARS INC (US) | 2019-01-30 | — | — | EP | disclosed |
| US-20180251479-A1 | INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS | MARS, INCORPORATED | 2018-09-06 | — | — | US | disclosed |
| US-20170183362-A1 | INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS | MARS, INCORPORATED | 2017-06-29 | — | — | US | disclosed |
| US-9040703-B2 | Inhibitors of arginase and their therapeutic applications | MARS, INCORPORATED (US) | 2015-05-26 | — | — | US | disclosed |
| US-20120083469-A1 | INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS | MARS, INCORPORATED | 2012-04-05 | — | — | US | disclosed |
| US-20040254178-A1 | Substituted heterocyclic compounds and methods of use | AMGEN INC. | 2004-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040254178-A1 | Substituted heterocyclic compounds and methods of use | MYLK2, MAPT, MUSK | HTT 852/4885SMN1; SMN2 9/4885NPC1 2806/4885 |
| US-20180251479-A1 | INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS | ARG1, ARG2, PRMT9 | HTT 4239/4885SMN1; SMN2 3556/4885NPC1 2297/4885 |
| US-20170183362-A1 | INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS | ARG1, ARG2, PRMT9 | HTT 4239/4885SMN1; SMN2 3556/4885NPC1 2297/4885 |
| US-20120083469-A1 | INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS | ARG1, ARG2, PRMT9 | HTT 4239/4885SMN1; SMN2 3556/4885NPC1 2297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.