Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | CTSA | P10619 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLQ | O75417 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16237694 | 0.80 | KDM4E (0.40) | KDM4ENPC1RAB9AABCG2DHODH | |
| SCHEMBL7528921 | 0.72 | ERN1 (0.37) | KDM4ENPC1RAB9ACYP1A2DHODH | |
| SCHEMBL62780 | 0.70 | KDM4E (0.40) | KDM4ENPC1RAB9ACYP1A2ABCG2 | |
| SCHEMBL17479068 | 0.70 | ABL1 (0.39) | KDM4ENPC1RAB9ACTSAMAPT | |
| SCHEMBL6465063 | 0.69 | KMT2A (0.44) | KDM4ECTSAMAPTALDH1A1KMT2A | |
| SCHEMBL3747564 | 0.69 | TSHR (0.43) | KDM4EABCG2SMN1; SMN2GAAPOLB | |
| SCHEMBL17613418 | 0.68 | LMNA (0.49) | KDM4ENPC1RAB9ADHODHSMN1; SMN2 | |
| SCHEMBL22551809 | 0.68 | KDM4E (0.46) | KDM4ENPC1RAB9ACTSASMN1; SMN2 | |
| SCHEMBL29907784 | 0.68 | KDM4E (0.46) | KDM4ENPC1RAB9ACTSASMN1; SMN2 | |
| SCHEMBL17613417 | 0.68 | LMNA (0.49) | KDM4ENPC1RAB9AABCG2DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000006565-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-02-10 | — | — | WO | disclosed |