SCHEMBL8167341

SCHEMBL8167341

C=CC(=O)OCCC[SiH2]C

nearest known ligand 0.63

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TSHR P16473 7/20 0.63
ALDH1A1 P00352 5/20 0.63
CYP3A4 P08684 2/20 0.63
HPGD P15428 1/20 0.62
TP53 P04637 3/20 0.52
HIF1A Q16665 3/20 0.52
HSD17B10 Q99714 1/20 0.52
THRB P10828 4/20 0.43
ATM Q13315 1/20 0.41
MAPK1 P28482 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
HCAR2 Q8TDS4 4/20 0.36
MAPT P10636 1/20 0.32
RAB9A P51151 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15309047 0.94 TSHR (0.67) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL30418857 0.92 TSHR (0.70) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL9546124 0.82 TSHR (0.55) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL1015618 0.82 TSHR (0.65) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL336349 0.81 TSHR (0.59) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL321925 0.80 TSHR (0.85) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL244114 0.80 TSHR (0.95) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL31333077 0.79 TSHR (0.57) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL1493269 0.79 TSHR (0.96) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL27622801 0.79 TSHR (0.96) TSHRALDH1A1CYP3A4HPGDTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2000041650-B1 LENSES CAPABLE OF POST-FABRICATION POWER MODIFICATION CALIFORNIA INST OF TECHN (US) 2000-10-19 WO claimed
CN-119320495-A Liquid crystal aligning agent, liquid crystal alignment film and liquid crystal display element 奇美实业股份有限公司 2025-01-17 CN disclosed
CN-117623493-A Anthraquinone modified pyrite and MBBR filler composition and preparation method thereof 厦门理工学院 2024-03-01 CN disclosed
CN-116546982-A Retinoic acid compositions and methods thereof 李兆阳 2023-08-04 CN disclosed
US-11370962-B1 Methods for designing coated proppant in low viscosity carrier fluid SAUDI ARABIAN OIL COMPANY (SA) 2022-06-28 US disclosed
CN-105980452-A Semiconductive polymer composition for electric power cables 博里利斯股份公司 2016-09-28 CN disclosed
CN-103764702-B Thermal shock resistant cured product and method for producing same 东亚合成株式会社 2016-08-31 CN disclosed
EP-0791016-A1 POLYMER SYNTHESIS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1997-08-27 EP disclosed
US-4722975-A VINYL-CONTAINING ORGANOSILICON ETHYLENICALLY UNSATURATED COMPOUND SHIN-ETSU CHEMICAL CO., LTD. (JP) 1988-02-02 US disclosed
WO-1983001777-A1 IMPROVED OXYGEN PERMEABLE HARD AND SEMI-HARD CONTACT LENS COMPOSITIONS, METHODS AND ARTICLES OF MANUFACTURE TSUETAKI GEORGE F (US) 1983-05-26 WO disclosed