SCHEMBL8167403

SCHEMBL8167403

CCNc1cccc(Cl)n1

nearest known ligand 0.59

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 1/20 0.51
CACNA1C Q13936 1/20 0.51
SCN5A Q14524 1/20 0.51
ALDH1A1 P00352 4/20 0.49
GAA P10253 3/20 0.46
MAPT P10636 1/20 0.46
HPGD P15428 1/20 0.46
AGTR1 P30556 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.44
CNR1 P21554 1/20 0.42
EGFR P00533 1/20 0.41
XPO1 O14980 1/20 0.41
GRM5 P41594 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14518469 0.84 SCN5A (0.66) KCNH2CACNA1CSCN5AMAPTCNR1
SCHEMBL29971364 0.77 CYP1A2 (0.48) ALDH1A1GAAMAPTHPGDAGTR1
SCHEMBL2324870 0.77 GRM5 (0.57) KCNH2CACNA1CSCN5AALDH1A1HPGD
SCHEMBL1646497 0.76 ALDH1A1 (0.51) ALDH1A1GAAMAPTHPGDAGTR1
SCHEMBL8348068 0.76 GRM5 (0.50) KCNH2CACNA1CSCN5AGRM5
SCHEMBL11446725 0.76 CYP2C19 (0.56) ALDH1A1GAAMAPTHPGDAGTR1
SCHEMBL3936695 0.76
SCHEMBL8351038 0.75 CACNA1C (0.51) KCNH2CACNA1CSCN5ACNR1GRM5
SCHEMBL99680 0.75 CACNA1C (0.51) KCNH2CACNA1CSCN5ACNR1GRM5
SCHEMBL22937086 0.75 CACNA1C (0.51) KCNH2CACNA1CSCN5ACNR1GRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008098857-A1 2-AMINOOXAZOLINES AS TAAR1 LIGANDS F. HOFFMANN-LA ROCHE AG (CH) 2008-08-21 WO disclosed
US-4617397-A HERBICIDES TOYO SODA MANUFACTURING CO., LTD. (JP) 1986-10-14 US disclosed
US-4560762-A HERBICIDE INTERMEDIATES TOYO SODA MANUFACTURING CO. LTD. (JP) 1985-12-24 US disclosed