Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 10/20 | 0.42 |
| ▸ | COMT | P21964 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL92299 | 0.88 | PDK2 (0.44) | PDK2SYKNPC1ALDH1A1RAB9A | |
| SCHEMBL22373946 | 0.81 | PDK2 (0.46) | PDK2COMTTNKS2NPC1ALDH1A1 | |
| SCHEMBL22373903 | 0.81 | PDK2 (0.41) | PDK2TNKS2NPC1ALDH1A1CYP1A2 | |
| SCHEMBL81678 | 0.81 | PDK2 (0.40) | PDK2NPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL81604 | 0.77 | PDK2 (0.41) | PDK2CYP1A2GAACYP2C19 | |
| SCHEMBL81614 | 0.77 | PDK2 (0.41) | PDK2CYP1A2GAACYP2C19 | |
| SCHEMBL19928405 | 0.76 | PDK2 (0.44) | PDK2 | |
| SCHEMBL81615 | 0.76 | PDK2 (0.39) | PDK2PGRBACE1NPC1CYP1A2 | |
| SCHEMBL24810030 | 0.75 | L3MBTL1 (0.40) | PDK2FLT3NPC1ALDH1A1GAA | |
| SCHEMBL9963989 | 0.75 | PDK2 (0.41) | PDK2PGRKCNH2NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129899-B1 | Azafluorene derivative and organic light-emitting device using the derivative | CANON KABUSHIKI KAISHA (JP) | 2012-03-06 | — | — | US | disclosed |
| US-20120049176-A1 | AZAFLUORENE DERIVATIVE AND ORGANIC LIGHT-EMITTING DEVICE USING THE DERIVATIVE | CANON KABUSHIKI KAISHA (JP) | 2012-03-01 | — | — | US | disclosed |