Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9065295 | 0.98 | TSHR (0.48) | TSHRALDH1A1ABCC4MAPTLMNA | |
| SCHEMBL9559191 | 0.95 | — | — | |
| SCHEMBL9486873 | 0.92 | TSHR (0.52) | TSHRALDH1A1ABCC4MAPTLMNA | |
| SCHEMBL28174666 | 0.92 | TSHR (0.52) | TSHRALDH1A1ABCC4MAPTLMNA | |
| SCHEMBL17242077 | 0.92 | TSHR (0.52) | TSHRALDH1A1ABCC4MAPTLMNA | |
| Hydrochloric Acid SCHEMBL9065293 | 0.88 | TSHR (0.48) | TSHRALDH1A1ABCC4MAPTLMNA | |
| SCHEMBL6910567 | 0.87 | — | — | |
| Hydrochloric Acid SCHEMBL6300555 | 0.81 | — | — | |
| SCHEMBL5969206 | 0.75 | — | — | |
| SCHEMBL14956560 | 0.73 | TSHR (0.38) | TSHRALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0810234-B1 | Method for making and using a supported metallocene catalyst system | PHILLIPS PETROLEUM CO (US) | 2000-02-16 | — | — | EP | disclosed |
| EP-0685495-B1 | Method for using a supported metallocene catalyst system | PHILLIPS PETROLEUM CO (US) | 1998-04-08 | — | — | EP | disclosed |
| EP-0810234-A2 | Method for making and using a supported metallocene catalyst system | PHILLIPS PETROLEUM COMPANY (US) | 1997-12-03 | — | — | EP | disclosed |
| EP-0685495-A1 | Method for making and using a supported metallocene catalyst system | PHILLIPS PETROLEUM COMPANY (US) | 1995-12-06 | — | — | EP | disclosed |