Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.43 |
| ▸ | CNR2 | P34972 | 5/20 | 0.36 |
| ▸ | CNR1 | P21554 | 4/20 | 0.35 |
| ▸ | HPGDS | O60760 | 2/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL870691 | 1.00 | PDE4B (0.43) | PDE4BCNR2CNR1HPGDSGPR55 | |
| SCHEMBL870690 | 1.00 | PDE4B (0.43) | PDE4BCNR2CNR1HPGDSGPR55 | |
| SCHEMBL870026 | 0.92 | PDE4B (0.45) | PDE4BCNR2CNR1HPGDS | |
| SCHEMBL870027 | 0.92 | PDE4B (0.45) | PDE4BCNR2CNR1HPGDS | |
| SCHEMBL870639 | 0.91 | PDE4B (0.45) | PDE4BCNR2CNR1 | |
| SCHEMBL870249 | 0.89 | PDE4B (0.42) | PDE4BCNR2CNR1HPGDSGPR55 | |
| SCHEMBL870250 | 0.89 | PDE4B (0.42) | PDE4BCNR2CNR1HPGDSGPR55 | |
| SCHEMBL8170582 | 0.87 | PDE4B (0.46) | PDE4BCNR2CNR1HPGDSGPR55 | |
| SCHEMBL870978 | 0.87 | PDE4B (0.46) | PDE4BCNR2CNR1HPGDSGPR55 | |
| SCHEMBL870977 | 0.87 | PDE4B (0.46) | PDE4BCNR2CNR1HPGDSGPR55 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008084223-A2 | CHEMICAL COMPOUNDS 637: PYRIDOPYRIMIDINEDIONES AS PDE4 INHIBITORS | ASTRAZENECA AB (SE) | 2008-07-17 | — | — | WO | disclosed |