Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 19/20 | 0.55 |
| ▸ | RARG | P13631 | 19/20 | 0.55 |
| ▸ | RARA | P10276 | 18/20 | 0.55 |
| ▸ | RXRA | P19793 | 7/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16593893 | 0.77 | SRD5A1 (0.47) | RARBRARGRARARXRAKDM4E | |
| SCHEMBL16593892 | 0.77 | SRD5A1 (0.47) | RARBRARGRARARXRAKDM4E | |
| SCHEMBL6759491 | 0.77 | RARB (0.67) | RARBRARGRARARXRAKDM4E | |
| SCHEMBL6236585 | 0.77 | RARB (0.67) | RARBRARGRARARXRAKDM4E | |
| SCHEMBL6236579 | 0.77 | RARB (0.67) | RARBRARGRARARXRAKDM4E | |
| SCHEMBL6297112 | 0.73 | RARA (0.50) | RARBRARGRARARXRANR2E1 | |
| SCHEMBL6297114 | 0.73 | RARA (0.50) | RARBRARGRARARXRANR2E1 | |
| SCHEMBL6292881 | 0.73 | RARA (0.49) | RARBRARGRARARXRANR2E1 | |
| SCHEMBL6292880 | 0.73 | RARA (0.49) | RARBRARGRARARXRANR2E1 | |
| SCHEMBL4666992 | 0.71 | RARB (0.68) | RARBRARGRARARXRAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6051731-A | TREATING SKIN DISORDERS, CANCERS, EYE DISORDERS, CARDIOVASCULAR DISORDERS, ELIMINATE OR REDUCE SIDE EFFECTS OF RETINOIDS, OR TO TREAT RETINOID OR VITAMIN A OVERDOSE OR POISONING | ALLERGAN SALES, INC. (US) | 2000-04-18 | — | — | US | disclosed |