Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 12/20 | 0.72 |
| ▸ | RXRB | P28702 | 8/20 | 0.72 |
| ▸ | RXRG | P48443 | 6/20 | 0.72 |
| ▸ | RARB | P10826 | 12/20 | 0.49 |
| ▸ | RARG | P13631 | 12/20 | 0.49 |
| ▸ | RARA | P10276 | 9/20 | 0.49 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.49 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5681944 | 0.88 | RXRA (0.71) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL5681942 | 0.88 | RXRA (0.71) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL8157745 | 0.88 | RXRA (0.71) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL7720657 | 0.84 | RXRA (1.00) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL8165219 | 0.84 | RXRA (0.64) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL7720632 | 0.81 | RXRA (0.78) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL8005377 | 0.79 | RXRA (0.74) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL5684444 | 0.78 | CYP26A1 (0.68) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL5684446 | 0.78 | CYP26A1 (0.68) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL5680238 | 0.78 | RXRA (0.81) | RXRARXRBRXRGRARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5985928-A | HUMAN OR VETERINARY MEDICINE FOR EXAMPLE DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1999-11-16 | — | — | US | claimed |
| EP-0722928-B1 | Bicyclic-aromatic compounds with strong biologic activity, pharmaceutical and cosmetic compositions containing them and uses thereof | CIRD GALDERMA (FR) | 1997-08-06 | — | — | EP | claimed |
| US-6156750-A | Bioactive bicyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2000-12-05 | — | — | US | disclosed |
| US-5985928-A | HUMAN OR VETERINARY MEDICINE FOR EXAMPLE DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1999-11-16 | — | — | US | disclosed |
| US-5763487-A | SKIN DISORDERS, CARDIOVASCULAR DISORDERS AND COSMETICS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-06-09 | — | — | US | disclosed |