Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 17/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.73 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.72 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.72 |
| ▸ | PDE2A | O00408 | 1/20 | 0.72 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.72 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.72 |
| ▸ | PDE6D | O43924 | 1/20 | 0.72 |
| ▸ | PDE8A | O60658 | 1/20 | 0.72 |
| ▸ | PDE9A | O76083 | 1/20 | 0.72 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.72 |
| ▸ | HTR1A | P08908 | 1/20 | 0.72 |
| ▸ | PDE6A | P16499 | 1/20 | 0.72 |
| ▸ | PDE6G | P18545 | 1/20 | 0.72 |
| ▸ | PDE4A | P27815 | 1/20 | 0.72 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.72 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.72 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.72 |
| ▸ | PDE6B | P35913 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1141 | 0.90 | PDE5A (1.00) | PDE5AKMT2APDE3BPDE3APDE2A | |
| SCHEMBL30199797 | 0.90 | PDE5A (1.00) | PDE5AKMT2APDE3BPDE3APDE2A | |
| SCHEMBL14836841 | 0.87 | PDE5A (0.94) | PDE5AKMT2APDE3BPDE3APDE2A | |
| SCHEMBL21995693 | 0.87 | KMT2A (0.83) | PDE5AKMT2APDE3BPDE3APDE2A | |
| SCHEMBL17390180 | 0.86 | PDE5A (0.72) | PDE5AKMT2APDE3BPDE3APDE2A | |
| SCHEMBL8803457 | 0.86 | PDE5A (0.72) | PDE5AKMT2APDE3BPDE3APDE2A | |
| SCHEMBL30848678 | 0.86 | PDE5A (0.95) | PDE5AKMT2APDE3BPDE3APDE2A | |
| SCHEMBL6628860 | 0.86 | KMT2A (0.85) | PDE5AKMT2APDE3BPDE3APDE2A | |
| SCHEMBL997 | 0.86 | PDE5A (0.89) | PDE5APDE3BPDE3APDE2AABCC4 | |
| SCHEMBL1071 | 0.85 | KMT2A (0.83) | PDE5AKMT2APDE3BPDE3APDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000043012-A1 | CONTROLLING HEART RATE OR BLOOD PRESSURE IN PATIENTS CO-MEDICATED WITH PHOSPHODIESTERASE INHIBITORS FOR TREATMENT OF IMPOTENCE | SELECTUS PHARMACEUTICALS, INC. (US) | 2000-07-27 | — | — | WO | disclosed |