Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | BCDIN3D | Q7Z5W3 | 2/20 | 0.41 |
| ▸ | PDE5A | O76074 | 8/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8171015 | 0.93 | ESR1 (0.47) | ESR1BCDIN3DPDE5AMEN1KMT2A | |
| SCHEMBL8184899 | 0.92 | ESR1 (0.49) | ESR1MEN1KMT2A | |
| SCHEMBL8179394 | 0.92 | MEN1 (0.48) | ESR1MEN1KMT2A | |
| SCHEMBL5115035 | 0.88 | ESR1 (0.48) | ESR1BCDIN3DPDE5AMEN1KMT2A | |
| SCHEMBL8182349 | 0.86 | PRKCI (0.43) | BCDIN3DPDE5AKMT2A | |
| SCHEMBL8177950 | 0.86 | BCDIN3D (0.41) | BCDIN3DPDE5AMEN1KMT2A | |
| SCHEMBL5814645 | 0.85 | ESR1 (0.46) | ESR1BCDIN3DPDE5AMEN1KMT2A | |
| SCHEMBL8171050 | 0.85 | KMT2A (0.50) | ESR1MEN1KMT2A | |
| SCHEMBL8176965 | 0.84 | ESR1 (0.50) | ESR1MEN1KMT2A | |
| SCHEMBL8184744 | 0.83 | CA1 (0.49) | ESR1PDE5AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |