Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 13/20 | 1.00 |
| ▸ | DRD2 | P14416 | 4/20 | 0.52 |
| ▸ | DRD3 | P35462 | 2/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8169645 | 1.00 | HTR1A (1.00) | HTR1ADRD2DRD3DRD4CHRM2 | |
| SCHEMBL5171731 | 0.94 | HTR1A (0.89) | HTR1ADRD2DRD3DRD4CHRM2 | |
| SCHEMBL5167251 | 0.94 | HTR1A (0.89) | HTR1ADRD2DRD3DRD4CHRM2 | |
| SCHEMBL5167242 | 0.94 | HTR1A (0.89) | HTR1ADRD2DRD3DRD4CHRM2 | |
| SCHEMBL5171727 | 0.94 | HTR1A (0.89) | HTR1ADRD2DRD3DRD4CHRM2 | |
| SCHEMBL10760426 | 0.92 | HTR1A (0.84) | HTR1ADRD2DRD3DRD4 | |
| SCHEMBL10760422 | 0.92 | HTR1A (0.84) | HTR1ADRD2DRD3DRD4 | |
| SCHEMBL10760431 | 0.92 | HTR1A (0.84) | HTR1ADRD2DRD3DRD4 | |
| SCHEMBL10761040 | 0.92 | HTR1A (0.84) | HTR1ADRD2DRD3DRD4 | |
| SCHEMBL7770661 | 0.86 | HTR1A (0.75) | HTR1ADRD2DRD3DRD4CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080752-A | FOR TREATING CONDITION WHICH REQUIRES ANTAGONISM OF A DOPAMINE RECEPTOR SUCH AS PSYCHTIC CONDITION | SMITHKLINE BEECHAM PLC (GB) | 2000-06-27 | — | — | US | disclosed |
| EP-0906284-A1 | TRICYCLIC AMINE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997047602-A1 | TRICYCLIC AMINE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1997-12-18 | — | — | WO | disclosed |