Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1B | P47901 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.37 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.36 |
| ▸ | AXL | P30530 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.36 |
| ▸ | MERTK | Q12866 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CHKA | P35790 | 2/20 | 0.35 |
| ▸ | WNT1 | P04628 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | SMO | Q99835 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3019156 | 1.00 | AVPR1B (0.39) | AVPR1BPDE4BTNIKSLC2A1AXL | |
| SCHEMBL870165 | 0.93 | AVPR1B (0.44) | AVPR1BPDE4BTNIKSLC2A1AXL | |
| SCHEMBL870166 | 0.93 | AVPR1B (0.44) | AVPR1BPDE4BTNIKSLC2A1AXL | |
| SCHEMBL870450 | 0.92 | AVPR1B (0.43) | AVPR1BPDE4BSLC2A1AXLFLT3 | |
| SCHEMBL870449 | 0.92 | AVPR1B (0.43) | AVPR1BPDE4BSLC2A1AXLFLT3 | |
| SCHEMBL3030807 | 0.92 | AVPR1B (0.41) | AVPR1BPDE4BTNIKSLC2A1AXL | |
| SCHEMBL3030814 | 0.92 | AVPR1B (0.41) | AVPR1BPDE4BTNIKSLC2A1AXL | |
| SCHEMBL870300 | 0.91 | AVPR1B (0.39) | AVPR1BPDE4BSLC2A1AXLFLT3 | |
| SCHEMBL870299 | 0.91 | AVPR1B (0.39) | AVPR1BPDE4BSLC2A1AXLFLT3 | |
| SCHEMBL870597 | 0.89 | PDE4B (0.38) | AVPR1BPDE4BTNIKSLC2A1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008084223-A2 | CHEMICAL COMPOUNDS 637: PYRIDOPYRIMIDINEDIONES AS PDE4 INHIBITORS | ASTRAZENECA AB (SE) | 2008-07-17 | — | — | WO | disclosed |