Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 3/20 | 0.65 |
| ▸ | PTPRA | P18433 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8165506 | 0.94 | FDPS (0.70) | FDPSPTPRAPGRADORA3PTGS1 | |
| SCHEMBL8167468 | 0.85 | FDPS (0.59) | FDPSPTPRAALDH1A1GRIN2DGRIN3B | |
| SCHEMBL8167866 | 0.85 | FDPS (0.69) | FDPSPTPRAALDH1A1GRIN2DGRIN3B | |
| SCHEMBL8166906 | 0.81 | FDPS (0.63) | FDPSPTPRAPGRADORA3PTGS1 | |
| Piridronic Acid SCHEMBL223779 | 0.79 | FDPS (1.00) | FDPSPTPRASMN1; SMN2ALDH1A1GRIN2D | |
| SCHEMBL10748069 | 0.78 | FDPS (0.48) | FDPSPTPRAPGRADORA3PTGS1 | |
| SCHEMBL8165637 | 0.74 | FDPS (0.64) | FDPSPTPRAPGRADORA3PTGS1 | |
| Piridronic Acid SCHEMBL634964 | 0.73 | FDPS (0.79) | FDPSPTPRASMN1; SMN2ALDH1A1GRIN2D | |
| SCHEMBL8166214 | 0.72 | FDPS (0.66) | FDPS | |
| SCHEMBL8168934 | 0.72 | FDPS (0.69) | FDPSCYP1A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0563107-B1 | NOVEL METHYLENEBISPHOSPHONIC ACID DERIVATIVES | LEIRAS OY (FI) | 2000-05-03 | — | — | EP | disclosed |
| US-5393748-A | Treating bone disorders, Paget* s disease, calcium metabolism disorders | LEIRAS OY (FI) | 1995-02-28 | — | — | US | disclosed |
| EP-0563107-A1 | NOVEL METHYLENEBISPHOSPHONIC ACID DERIVATIVES | LEIRAS OY (FI) | 1993-10-06 | — | — | EP | disclosed |
| WO-1992011269-A1 | NOVEL METHYLENEBISPHOSPHONIC ACID DERIVATIVES | LEIRAS OY (FI) | 1992-07-09 | — | — | WO | disclosed |