Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.40 |
| ▸ | MDM4 | O15151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 3/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8173102 | 0.78 | MAPT (0.41) | MAPTLMNAMDM2MDM4L3MBTL1 | |
| SCHEMBL7023950 | 0.72 | HCAR2 (0.47) | MAPTLMNAMDM2L3MBTL1ALDH1A1 | |
| SCHEMBL8242959 | 0.72 | HCAR2 (0.47) | MAPTLMNAMDM2L3MBTL1ALDH1A1 | |
| SCHEMBL8179462 | 0.70 | MAPT (0.59) | MAPTLMNAMDM2L3MBTL1ALDH1A1 | |
| SCHEMBL5405527 | 0.70 | MAPT (0.56) | MAPTLMNAMDM2MDM4MMP8 | |
| SCHEMBL5405533 | 0.70 | MAPT (0.56) | MAPTLMNAMDM2MDM4MMP8 | |
| SCHEMBL6263496 | 0.69 | MAPT (0.57) | MAPTLMNAMDM2MDM4ALDH1A1 | |
| SCHEMBL6263498 | 0.69 | MAPT (0.57) | MAPTLMNAMDM2MDM4ALDH1A1 | |
| SCHEMBL13039748 | 0.69 | HCAR2 (0.62) | MAPTLMNAL3MBTL1ALDH1A1HCAR2 | |
| SCHEMBL30999261 | 0.69 | MAPT (0.48) | MAPTLMNAMDM2MDM4L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008088690-A2 | A PROCESS FOR PREPARING DIAZABICYCLO[3.3.1] NONANE COMPOUNDS | MERCK & CO., INC. (US) | 2008-07-24 | — | — | WO | disclosed |