Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.71 |
| ▸ | HPGD | P15428 | 4/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.64 |
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | POLB | P06746 | 5/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.63 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.63 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | APEX1 | P27695 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14281352 | 0.84 | HPGD (0.66) | SMN1; SMN2HPGDALDH1A1L3MBTL1MAPT | |
| SCHEMBL9911427 | 0.83 | TSHR (0.60) | SMN1; SMN2HPGDTSHRALDH1A1L3MBTL1 | |
| SCHEMBL29410065 | 0.83 | ALDH1A1 (0.74) | HPGDTSHRALDH1A1L3MBTL1MAPT | |
| SCHEMBL18769149 | 0.81 | HSD17B10 (0.67) | SMN1; SMN2HPGDALDH1A1L3MBTL1MAPT | |
| SCHEMBL6360360 | 0.81 | ALDH1A1 (0.68) | SMN1; SMN2HPGDTSHRALDH1A1L3MBTL1 | |
| SCHEMBL12861415 | 0.80 | ALDH1A1 (0.73) | SMN1; SMN2HPGDTSHRALDH1A1L3MBTL1 | |
| SCHEMBL6289033 | 0.80 | ALDH1A1 (0.70) | HPGDTSHRALDH1A1L3MBTL1MAPT | |
| SCHEMBL9912447 | 0.80 | ALDH1A1 (0.70) | HPGDTSHRALDH1A1L3MBTL1MAPT | |
| SCHEMBL2926521 | 0.79 | ALDH1A1 (0.69) | SMN1; SMN2HPGDALDH1A1L3MBTL1MAPT | |
| SCHEMBL2638805 | 0.78 | ALDH1A1 (0.68) | HPGDTSHRALDH1A1L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030984-A | 7-(4-PHENOXYPHENYL)-6-OXOQUINOLIZINES AND DERIVATIVES OF TRICYCLIC RING ANALOGUES, PARTICULARLY 7-OXOTHIENO-(2,3-A)QUINOLIZINE; INHIBITING BETA-AMYLOID PEPTIDE ACTIVITY | HOFFMANN-LA ROCHE INC. (US) | 2000-02-29 | — | — | US | disclosed |
| US-5869500-A | INHIBITING BETA-AMYLOID PEPTIDE ACTIVITY | HOFFMANN-LA ROCHE INC. (US) | 1999-02-09 | — | — | US | disclosed |
| WO-1998025930-A2 | USE OF BI- AND TRICYCLIC PYRIDONE DERIVATIVES AGAINST ALZHEIMER'S DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 1998-06-18 | — | — | WO | disclosed |