Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 16/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.44 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30233086 | 0.88 | HRH3 (0.59) | HRH3KCNH2CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL8176884 | 0.87 | HRH3 (0.63) | HRH3KCNH2CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL8167962 | 0.86 | HRH3 (0.55) | HRH3KCNH2 | |
| SCHEMBL16600284 | 0.78 | HRH3 (0.68) | HRH3KCNH2CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL2800715 | 0.77 | HRH3 (0.78) | HRH3KCNH2 | |
| SCHEMBL2829052 | 0.74 | HRH3 (0.63) | HRH3KCNH2HSD11B1 | |
| SCHEMBL8165630 | 0.73 | HRH3 (0.37) | HRH3KCNH2 | |
| SCHEMBL24433453 | 0.72 | HRH3 (0.86) | HRH3KCNH2 | |
| SCHEMBL27209196 | 0.72 | CHRNB2 (0.55) | HRH3CHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL13232434 | 0.70 | HRH3 (0.58) | HRH3KCNH2CHRNB2CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100168105-A1 | Spirocyclopropyl Piperidine Derivatives | ASTRAZENECA AB (SE) | 2010-07-01 | — | — | US | disclosed |
| US-20100168105-A1 | Spirocyclopropyl Piperidine Derivatives | ASTRAZENECA AB (SE) | 2010-07-01 | — | — | US | disclosed |
| WO-2008147314-A1 | SPIROCYCLOPROPYL PIPERIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-12-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168105-A1 | Spirocyclopropyl Piperidine Derivatives | HRH3, HRH2, HRH4 | HRH3 1/4885KCNH2 1140/4885CHRNB2 515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.