Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.42 |
| ▸ | RELA | Q04206 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3063760 | 0.96 | GRM1 (0.37) | NPC1MEN1KMT2ARAB9AMAPT | |
| SCHEMBL3068075 | 0.93 | MAPT (0.35) | NPC1MEN1KMT2ARAB9AMAPT | |
| SCHEMBL3058858 | 0.92 | MEN1 (0.44) | NPC1MEN1KMT2ARAB9AMAPT | |
| SCHEMBL3068329 | 0.90 | GRIN2A (0.39) | MAPTMAPK1ALDH1A1GAAGRM1 | |
| SCHEMBL3059269 | 0.89 | KMT2A (0.42) | NPC1MEN1KMT2ARAB9AMAPT | |
| SCHEMBL3055945 | 0.88 | MEN1 (0.41) | NPC1MEN1KMT2ARAB9AMAPT | |
| SCHEMBL3060134 | 0.85 | POLB (0.36) | NPC1MEN1KMT2ARAB9AMAPT | |
| SCHEMBL3071357 | 0.84 | LMNA (0.50) | NPC1RAB9AMAPTLMNAHPGD | |
| SCHEMBL3065115 | 0.84 | GRIN1 (0.42) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL3064265 | 0.83 | POLB (0.46) | MEN1KMT2AMAPTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073929-A1 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |