Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13395963 | 0.89 | PDE4A (0.39) | PDE4APDE4DPDE4BPDE3BPDE3A | |
| SCHEMBL3306949 | 0.83 | PDE4A (0.44) | PDE4APDE4DPDE4BPDE3BPDE3A | |
| SCHEMBL3303735 | 0.82 | PDE4A (0.43) | PDE4APDE4DPDE4BPDE3BPDE3A | |
| SCHEMBL3305354 | 0.80 | PDE4A (0.49) | PDE4APDE4DPDE4BPDE3BPDE3A | |
| SCHEMBL18857435 | 0.80 | PDE4A (0.48) | PDE4APDE4DPDE4BPDE3BPDE3A | |
| SCHEMBL3299351 | 0.79 | PDE4A (0.62) | PDE4APDE4DPDE4BPDE3BPDE3A | |
| SCHEMBL3308369 | 0.79 | PDE4A (0.47) | PDE4AALDH1A1HSD17B10HIF1A | |
| SCHEMBL3306371 | 0.78 | PDE4A (0.44) | PDE4APDE4DPDE4BPDE3BPDE3A | |
| SCHEMBL3305218 | 0.78 | PDE4A (0.45) | PDE4APDE4DKDM4ECASP1CASP7 | |
| SCHEMBL17375277 | 0.78 | KDM4E (0.54) | PDE4APDE4DPDE4BKDM4ECASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008104175-A2 | NOVEL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2008-09-04 | — | — | WO | disclosed |