⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3249882 | 0.88 | ALDH1A1 (0.32) | — | |
| SCHEMBL3249701 | 0.85 | SSTR4 (0.32) | — | |
| SCHEMBL12066338 | 0.73 | ALDH1A1 (0.35) | — | |
| SCHEMBL12066331 | 0.73 | — | — | |
| SCHEMBL709949 | 0.69 | — | — | |
| SCHEMBL13539835 | 0.69 | ALDH1A1 (0.32) | — | |
| SCHEMBL12329999 | 0.69 | — | — | |
| SCHEMBL11255651 | 0.67 | ALDH1A1 (0.30) | — | |
| SCHEMBL807036 | 0.67 | ALDH1A1 (0.30) | — | |
| SCHEMBL27284399 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110275872-A1 | PROCESS FOR THE SYNTHESIS OF ETHYNYLCYCLOPROPANE | LONZA LTD (CH) | 2011-11-10 | — | — | US | claimed |
| EP-2260014-B1 | PROCESS FOR THE SYNTHESIS OF ETHYNYLCYCLOPROPANE | LONZA AG (CH) | 2011-09-28 | — | — | EP | claimed |
| EP-2260014-A1 | PROCESS FOR THE SYNTHESIS OF ETHYNYLCYCLOPROPANE | Lonza Ltd. (CH) | 2010-12-15 | — | — | EP | claimed |
| WO-2009118179-A1 | PROCESS FOR THE SYNTHESIS OF ETHYNYLCYCLOPROPANE | LONZA LTD (CH) | 2009-10-01 | — | — | WO | claimed |
| EP-0922686-B1 | Process for the preparation of ethynylcyclopropane | LONZA AG (CH) | 2002-02-06 | — | — | EP | claimed |
| US-6002062-A | Process for the preparation of ethynylcyclopropane | LONZA AG (CH) | 1999-12-14 | — | — | US | claimed |
| EP-0922686-A1 | Process for the preparation of ethynylcyclopropane | LONZA A.G. (CH) | 1999-06-16 | — | — | EP | claimed |
| CN-113461657-B | Organic small molecule gel and preparation method and application thereof | 天津大学 | 2022-05-17 | — | — | CN | disclosed |
| CN-113461657-A | Organic small molecule gel and preparation method and application thereof | 天津大学 | 2021-10-01 | — | — | CN | disclosed |
| CN-107721796-B | Preparation method of substituted alkynyl cyclopropyl-containing compound | 宁波九胜创新医药科技有限公司 | 2020-12-11 | — | — | CN | disclosed |
| CN-107698417-B | Preparation method of alkynyl-containing cyclopropyl compound | 宁波九胜创新医药科技有限公司 | 2020-08-25 | — | — | CN | disclosed |
| CN-107721796-A | A kind of preparation method of the compound of ciprofloxacin eye drops containing substituted alkynyl | 宁波九胜创新医药科技有限公司 | 2018-02-23 | — | — | CN | disclosed |
| CN-107698417-A | A kind of preparation method of the compound of ciprofloxacin eye drops containing alkynyl | 宁波九胜创新医药科技有限公司 | 2018-02-16 | — | — | CN | disclosed |
| EP-0922686-B1 | Process for the preparation of ethynylcyclopropane | LONZA AG (CH) | 2002-02-06 | — | — | EP | disclosed |
| US-6002062-A | Process for the preparation of ethynylcyclopropane | LONZA AG (CH) | 1999-12-14 | — | — | US | disclosed |
| US-6002062-A | Process for the preparation of ethynylcyclopropane | LONZA AG (CH) | 1999-12-14 | — | — | US | disclosed |
| EP-0931103-A1 | MONOMERS, OLIGOMERS AND POLYMERS WITH TERMINAL OXIRANE GROUPS, METHOD OF PREPARATION AND POLYMERISATION UNDER RADIATION EXPOSURE | UCB, S.A. (BE) | 1999-07-28 | — | — | EP | disclosed |
| EP-0922686-A1 | Process for the preparation of ethynylcyclopropane | LONZA A.G. (CH) | 1999-06-16 | — | — | EP | disclosed |
| EP-0922686-A1 | Process for the preparation of ethynylcyclopropane | LONZA A.G. (CH) | 1999-06-16 | — | — | EP | disclosed |
| WO-1998014497-A1 | MONOMERS, OLIGOMERS AND POLYMERS WITH TERMINAL OXIRANE GROUPS, METHOD OF PREPARATION AND POLYMERISATION UNDER RADIATION EXPOSURE | UCB, S.A. (BE) | 1998-04-09 | — | — | WO | disclosed |