Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.55 |
| ▸ | KDM4A | O75164 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 3/20 | 0.44 |
| ▸ | CTSS | P25774 | 2/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | SDCBP | O00560 | 1/20 | 0.41 |
| ▸ | SDC2 | P34741 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8184051 | 0.89 | HDAC1 (0.52) | HDAC1KDM4ACTSKCTSSCTSB | |
| SCHEMBL28425305 | 0.87 | HDAC1 (0.53) | HDAC1KDM4ACTSKCTSSCTSB | |
| SCHEMBL28646590 | 0.86 | HDAC1 (0.59) | HDAC1KDM4ACTSKCTSSCTSB | |
| SCHEMBL4953918 | 0.85 | ACLY (0.56) | HDAC1KDM4ACTSKCTSSCTSB | |
| SCHEMBL6874894 | 0.83 | KCNA5 (0.52) | HDAC1KDM4ACTSKCTSSKCNA5 | |
| SCHEMBL30454240 | 0.83 | KCNA5 (0.52) | HDAC1KDM4ACTSKCTSSKCNA5 | |
| SCHEMBL1691047 | 0.82 | HDAC1 (0.67) | HDAC1KDM4ACTSKCTSSNAMPT | |
| SCHEMBL17059395 | 0.82 | NR1H4 (0.48) | HDAC1KDM4AKCNA5NAMPTHDAC10 | |
| SCHEMBL18664426 | 0.81 | HDAC1 (0.60) | HDAC1KDM4ACTSKCTSSCTSB | |
| SCHEMBL6242494 | 0.80 | HDAC1 (0.55) | HDAC1KDM4ACTSKCTSSCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080870-A | Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors | MERCK & CO., INC. (US) | 2000-06-27 | — | — | US | disclosed |
| EP-0891333-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036875-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |