SCHEMBL8176176

SCHEMBL8176176

COC(=O)c1cc2c(Cl)cc(F)c(-n3c(=O)cc(C(F)(F)F)n(C)c3=O)c2o1

nearest known ligand 0.36

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 1/20 0.32
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9430544 0.93 NOTUM (0.31) NOTUMMAPT
SCHEMBL8176209 0.89
SCHEMBL8175815 0.89 GPR35 (0.32)
SCHEMBL8176636 0.87
SCHEMBL8183413 0.86
SCHEMBL8541056 0.86
SCHEMBL8168311 0.82 CYP1A1 (0.30)
SCHEMBL9429794 0.82 GPR35 (0.32)
SCHEMBL8169432 0.82 DHODH (0.30)
SCHEMBL8176717 0.81 PDE4A (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6130187-A Benzofuran-7-yl uracil derivatives and herbicides KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 2000-10-10 US disclosed
EP-0881223-A1 BENZOFURAN-7-YLURACIL DERIVATIVES AND HERBICIDES KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1998-12-02 EP disclosed