Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 8/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8178327 | 0.94 | MEN1 (0.55) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8177879 | 0.93 | MEN1 (0.45) | MEN1KMT2APDE5ABCDIN3D | |
| SCHEMBL8177848 | 0.92 | PDE5A (0.46) | MEN1KMT2APDE5APDE4BPTGER4 | |
| SCHEMBL8185064 | 0.90 | PDE5A (0.45) | MEN1KMT2APDE5APDE4BPTGER4 | |
| SCHEMBL8183537 | 0.89 | PDE5A (0.45) | MEN1KMT2APDE5APDE4BPTGER4 | |
| SCHEMBL8178013 | 0.89 | FYN (0.48) | MEN1KMT2APDE5ACYP1A2CYP3A4 | |
| SCHEMBL8178577 | 0.88 | PDE5A (0.47) | MEN1KMT2APDE5APDE4BPTGER4 | |
| SCHEMBL5125325 | 0.87 | PDE5A (0.48) | MEN1KMT2APDE5ABCDIN3D | |
| SCHEMBL8178389 | 0.86 | MEN1 (0.52) | MEN1KMT2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8179358 | 0.85 | MEN1 (0.44) | MEN1KMT2APDE5ABCDIN3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |