Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | USP1 | O94782 | 2/20 | 0.43 |
| ▸ | WDR48 | Q8TAF3 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8184850 | 0.90 | FYN (0.47) | FYNUSP1WDR48HSD17B10EPHX2 | |
| SCHEMBL8180648 | 0.89 | CLK4 (0.42) | FYNUSP1WDR48HSD17B10MEN1 | |
| SCHEMBL8178180 | 0.89 | LMNA (0.48) | HSD17B10MEN1KMT2ACYP1A2CYP2D6 | |
| SCHEMBL8177243 | 0.89 | MEN1 (0.47) | HSD17B10MEN1KMT2AKDM4ECYP1A2 | |
| SCHEMBL8171209 | 0.89 | CYP1A2 (0.53) | HSD17B10MEN1KMT2ACYP1A2CYP2D6 | |
| SCHEMBL8184863 | 0.88 | PRKCI (0.48) | FYNUSP1WDR48HSD17B10EPHX2 | |
| SCHEMBL8183027 | 0.88 | USP1 (0.48) | FYNUSP1WDR48HSD17B10EPHX2 | |
| SCHEMBL8179818 | 0.87 | FYN (0.44) | FYNUSP1WDR48HSD17B10EPHX2 | |
| SCHEMBL8178327 | 0.85 | MEN1 (0.55) | HSD17B10MEN1KMT2AKDM4ECYP1A2 | |
| SCHEMBL5128113 | 0.85 | PRKCI (0.47) | USP1WDR48PDE5ARPS6KB1CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |