SCHEMBL8178

SCHEMBL8178

c1ccc(C(c2ccccc2)(c2ccccc2)C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.53

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KCNN4 O15554 4/20 0.53
ALDH1A1 P00352 4/20 0.53
TSHR P16473 2/20 0.53
MAPK1 P28482 1/20 0.45
CYP1A2 P05177 2/20 0.41
TAAR1 Q96RJ0 1/20 0.41
ALOX15 P16050 1/20 0.41
ESR1 P03372 2/20 0.39
ESR2 Q92731 2/20 0.39
PTPN1 P18031 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8216938 0.79 MAPK1 (0.50) KCNN4ALDH1A1TSHRMAPK1TAAR1
SCHEMBL160204 0.79 TSHR (0.58) KCNN4ALDH1A1TSHRMAPK1CYP1A2
SCHEMBL1001137 0.79 CYP1A2 (0.44) KCNN4ALDH1A1TSHRMAPK1CYP1A2
SCHEMBL28484493 0.79 TSHR (0.58) KCNN4ALDH1A1TSHRMAPK1CYP1A2
SCHEMBL754613 0.77 CYP1A2 (0.42) KCNN4ALDH1A1TSHRMAPK1CYP1A2
SCHEMBL6735941 0.77 MAPK1 (0.48) KCNN4ALDH1A1TSHRMAPK1TAAR1
SCHEMBL909523 0.77 KCNN4 (0.41) KCNN4ALDH1A1TSHRMAPK1CYP1A2
SCHEMBL7151184 0.77 KCNN4 (0.41) KCNN4ALDH1A1TSHRMAPK1CYP1A2
SCHEMBL230628 0.75 KCNN4 (0.53) KCNN4ALDH1A1TSHRMAPK1CYP1A2
SCHEMBL1538898 0.72 ALDH1A1 (0.50) KCNN4ALDH1A1TSHRMAPK1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1335 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230293713-A1 ANTI-TM4SF1 ANTIBODY DRUG CONJUGATES AND METHODS OF USING SAME ANGIEX, INC. 2023-09-21 US claimed
EP-3560937-B1 METHODS OF PREPARING 18F-LABELED PSMA-TARGETED PET IMAGING AGENTS AND DIAGNOSTIC METHODS THEREWITH CANCER TARGETED TECH LLC (US) 2022-12-28 EP claimed
WO-2021222783-A1 ANTI-TM4SF1 ANTIBODY DRUG CONJUGATES AND METHODS OF USING SAME ANGIEX, INC. (US) 2021-11-04 WO claimed
CN-108968888-B Portable neuroendoscopy system suitable for marine naval vessel uses 中国人民解放军第二军医大学第二附属医院 2021-01-29 CN claimed
EP-3036227-B1 PROCESS FOR PREPARING A COMPOUND GENENTECH INC (US) 2020-01-08 EP claimed
EP-2970345-B1 18F-LABELED PSMA-TARGETED PET IMAGING AGENTS CANCER TARGETED TECH LLC (US) 2019-06-19 EP claimed
CN-108968888-A A kind of portable nerve endoscope system used suitable for marine vessel 中国人民解放军第二军医大学第二附属医院 2018-12-11 CN claimed
CN-106083807-B 4- amino -5- biphenyl -4- base -2- methylol -2- methvl-pentanoic acid compounds and preparation method thereof 施万生物制药研发IP有限责任公司 2018-09-11 CN claimed
WO-2018150386-A1 AN IMPROVED PROCESS FOR THE PREPARATION OF BORONIC ACID ESTERS FRESENIUS KABI ONCOLOGY LTD. (IN) 2018-08-23 WO claimed
CN-106083807-A 4 amino 5 biphenyl 4 base 2 methylol 2 methylvaleric acid compounds and preparation method thereof 施万生物制药研发IP有限责任公司 2016-11-09 CN claimed
US-6194509-B1 VULCANIZABLE FILLER-REINFORCED, ELASTOMER-CONTAINING COMPOSITION COMPRISING ELASTOMER, REINFORCING FILLER, FREE RADICAL CAPPING ADDITIVE, CURE AGENT; PNEUMATIC TIRE COMPRISING A TREAD STOCK MANUFACTURED FROM THE COMPOSITION BRIDGESTONE CORPORATION (JP) 2001-02-27 US claimed
US-5420149-A Hypotensive agents and artheriosclerosis BAYER AKTIENGESELLSCHAFT (DE) 1995-05-30 US claimed
EP-0428708-B1 PROCESS FOR PREPARING A POLYMER HAVING PERFLUOROCYCLOBUTANE RINGS AND POLYMERS CONTAINING PERFLUOROCYCLOBUTANE RINGS DOW CHEMICAL CO (US) 1994-10-05 EP claimed
US-5352687-A Hypotensive agents BAYER AKTIENGESELLSCHAFT (DE) 1994-10-04 US claimed
EP-0428706-B1 PERFLUOROVINYL COMPOUNDS DOW CHEMICAL CO (US) 1994-07-13 EP claimed
US-5066746-A Dielectric Fluids, Lubricants And Plastics THE DOW CHEMICAL COMPANY (US) 1991-11-19 US claimed
EP-0428708-A1 PROCESS FOR PREPARING A POLYMER HAVING PERFLUOROCYCLOBUTANE RINGS AND POLYMERS CONTAINING PERFLUOROCYCLOBUTANE RINGS. DOW CHEMICAL CO (US) 1991-05-29 EP claimed
EP-0428706-A1 PERFLUOROVINYL COMPOUNDS. DOW CHEMICAL CO (US) 1991-05-29 EP claimed
WO-1990015043-A2 PERFLUOROVINYL COMPOUNDS THE DOW CHEMICAL COMPANY (US) 1990-12-13 WO claimed
WO-1990015082-A1 PROCESS FOR PREPARING A POLYMER HAVING PERFLUOROCYCLOBUTANE RINGS AND POLYMERS CONTAINING PERFLUOROCYCLOBUTANE RINGS THE DOW CHEMICAL COMPANY (US) 1990-12-13 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230293713-A1 ANTI-TM4SF1 ANTIBODY DRUG CONJUGATES AND METHODS OF USING SAME TM9SF4, TM9SF2, TM9SF3 KCNN4 3800/4885ALDH1A1 2644/4885TSHR 1295/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.