Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 16/20 | 0.85 |
| ▸ | PSMB1 | P20618 | 10/20 | 0.85 |
| ▸ | PSMB2 | P49721 | 10/20 | 0.85 |
| ▸ | PSMB11 | A5LHX3 | 9/20 | 0.85 |
| ▸ | PSMA7 | O14818 | 9/20 | 0.85 |
| ▸ | PSMA1 | P25786 | 9/20 | 0.85 |
| ▸ | PSMA2 | P25787 | 9/20 | 0.85 |
| ▸ | PSMA3 | P25788 | 9/20 | 0.85 |
| ▸ | PSMA4 | P25789 | 9/20 | 0.85 |
| ▸ | PSMB8 | P28062 | 9/20 | 0.85 |
| ▸ | PSMB9 | P28065 | 9/20 | 0.85 |
| ▸ | PSMA5 | P28066 | 9/20 | 0.85 |
| ▸ | PSMB4 | P28070 | 9/20 | 0.85 |
| ▸ | PSMB6 | P28072 | 9/20 | 0.85 |
| ▸ | PSMB10 | P40306 | 9/20 | 0.85 |
| ▸ | PSMB3 | P49720 | 9/20 | 0.85 |
| ▸ | PSMA6 | P60900 | 9/20 | 0.85 |
| ▸ | PSMA8 | Q8TAA3 | 9/20 | 0.85 |
| ▸ | PSMB7 | Q99436 | 9/20 | 0.85 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8126861 | 1.00 | PSMB5 (0.85) | PSMB5PSMB1PSMB2PSMB11PSMA7 | |
| SCHEMBL8178533 | 1.00 | PSMB5 (0.85) | PSMB5PSMB1PSMB2PSMB11PSMA7 | |
| SCHEMBL8183419 | 1.00 | PSMB5 (0.85) | PSMB5PSMB1PSMB2PSMB11PSMA7 | |
| SCHEMBL12137120 | 0.94 | PSMB5 (0.93) | PSMB5PSMB1PSMB2PSMB11PSMA7 | |
| SCHEMBL12137121 | 0.94 | PSMB5 (0.93) | PSMB5PSMB1PSMB2PSMB11PSMA7 | |
| Hydroxysalinosporamide A SCHEMBL23266050 | 0.93 | PSMB5 (0.85) | PSMB5PSMB1PSMB2PSMB11PSMA7 | |
| Hydroxysalinosporamide A SCHEMBL8170369 | 0.93 | PSMB5 (0.85) | PSMB5PSMB1PSMB2PSMB11PSMA7 | |
| Hydroxysalinosporamide A SCHEMBL8170234 | 0.93 | PSMB5 (0.85) | PSMB5PSMB1PSMB2PSMB11PSMA7 | |
| Hydroxysalinosporamide A SCHEMBL6380446 | 0.93 | PSMB5 (0.85) | PSMB5PSMB1PSMB2PSMB11PSMA7 | |
| Hydroxysalinosporamide A SCHEMBL8170371 | 0.93 | PSMB5 (0.85) | PSMB5PSMB1PSMB2PSMB11PSMA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003802-B2 | Total synthesis of Salinosporamide A and analogs thereof | NEREUS PHARMACEUTICALS, INC. (US) | 2011-08-23 | — | — | US | disclosed |
| US-20090234137-A1 | TOTAL SYNTHESIS OF SALINOSPORAMIDE A AND ANALOGS THEREOF | NEREUS PHARMACEUTICALS, INC. (US) | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090234137-A1 | TOTAL SYNTHESIS OF SALINOSPORAMIDE A AND ANALOGS THEREOF | ERG28, CYP51A1, EIF4A2 | PSMB5 2700/4885PSMB1 3493/4885PSMB2 2769/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.