Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 3/20 | 0.39 |
| ▸ | OXTR | P30559 | 7/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | TEK | Q02763 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | LIPE | Q05469 | 1/20 | 0.35 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1581627 | 0.94 | TACR1 (0.40) | TACR1OXTRPPARDPPARATRPM8 | |
| SCHEMBL8194590 | 0.93 | TACR1 (0.41) | TACR1OXTRPPARDPPARATRPM8 | |
| SCHEMBL1581533 | 0.90 | TACR1 (0.42) | TACR1OXTRTRPM8NPC1MAPT | |
| SCHEMBL264114 | 0.88 | TACR1 (0.39) | TACR1OXTRPPARDPPARATRPM8 | |
| SCHEMBL264115 | 0.88 | TACR1 (0.39) | TACR1OXTRPPARDPPARATRPM8 | |
| SCHEMBL264116 | 0.88 | TACR1 (0.39) | TACR1OXTRPPARDPPARATRPM8 | |
| SCHEMBL265200 | 0.81 | TSHR (0.39) | OXTRPPARDPPARATRPM8NPC1 | |
| SCHEMBL265201 | 0.81 | TSHR (0.39) | OXTRPPARDPPARATRPM8NPC1 | |
| SCHEMBL265202 | 0.81 | TSHR (0.39) | OXTRPPARDPPARATRPM8NPC1 | |
| SCHEMBL8194576 | 0.80 | TACR1 (0.48) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008110488-A1 | MALONAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-18 | — | — | WO | disclosed |