Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 7/20 | 0.67 |
| ▸ | CA9 | Q16790 | 2/20 | 0.66 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.63 |
| ▸ | PPARG | P37231 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8180180 | 1.00 | AKR1B1 (0.67) | AKR1B1CA9PTPN1PPARG | |
| SCHEMBL8204543 | 0.96 | AKR1B1 (0.66) | AKR1B1CA9PTPN1PPARG | |
| SCHEMBL8204542 | 0.96 | AKR1B1 (0.66) | AKR1B1CA9PTPN1PPARG | |
| SCHEMBL6879204 | 0.85 | AKR1B1 (0.70) | AKR1B1PTPN1 | |
| SCHEMBL6879207 | 0.85 | AKR1B1 (0.70) | AKR1B1PTPN1 | |
| SCHEMBL20534607 | 0.82 | AKR1B1 (0.78) | AKR1B1CA9PPARG | |
| SCHEMBL20534368 | 0.82 | AKR1B1 (0.78) | AKR1B1CA9PPARG | |
| SCHEMBL8186338 | 0.82 | AKR1B1 (0.70) | AKR1B1CA9PTPN1PPARG | |
| SCHEMBL8186339 | 0.82 | AKR1B1 (0.70) | AKR1B1CA9PTPN1PPARG | |
| SCHEMBL6887171 | 0.81 | PTPN12 (0.70) | AKR1B1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018746-A1 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |