Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CETP | P11597 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | UBE2N | P61088 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8180450 | 1.00 | CYP2D6 (0.39) | CYP2D6SPHK1TP53GMNNLMNA | |
| SCHEMBL18923209 | 1.00 | CYP2D6 (0.39) | CYP2D6SPHK1TP53GMNNLMNA | |
| SCHEMBL8975436 | 0.80 | CETP (0.37) | CETP | |
| SCHEMBL9418108 | 0.77 | SPHK1 (0.40) | CYP2D6SPHK1TP53GMNNLMNA | |
| SCHEMBL9418110 | 0.77 | SPHK1 (0.40) | CYP2D6SPHK1TP53GMNNLMNA | |
| SCHEMBL3295923 | 0.77 | CETP (0.36) | KDM4ECETPTDP1 | |
| SCHEMBL26780682 | 0.77 | CETP (0.36) | KDM4ECETPTDP1 | |
| SCHEMBL18124784 | 0.76 | SPHK1 (0.34) | SPHK1MAPTOPRM1CA1CA2 | |
| SCHEMBL18124785 | 0.76 | SPHK1 (0.34) | SPHK1MAPTOPRM1CA1CA2 | |
| SCHEMBL18125144 | 0.76 | SPHK1 (0.34) | SPHK1MAPTOPRM1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6017887-A | Peptide, peptide analog and amino acid analog protease inhibitors | SIBIA NEUROSCIENCES, INC. (US) | 2000-01-25 | — | — | US | claimed |
| US-5872101-A | Methods of treating neurodegenerative disorders using protease inhibitors | SIBIA NEUROSCIENCES, INC. (US) | 1999-02-16 | — | — | US | claimed |
| US-5863902-A | Methods of treating neurodegenerative disorders using protease inhibitors | SIBIA NEUROSCIENCES, INC. (US) | 1999-01-26 | — | — | US | claimed |
| US-6153171-A | Methods for identifying compounds effective for treating neurodegenerative disorders and for monitoring the therapeutic intervention therefor | SIBIA NEUROSCIENCES, INC. (US) | 2000-11-28 | — | — | US | disclosed |
| US-6051684-A | CONTACTING A COMPOSITION CONTAINING AMYLOID PRECURSOR PROTEIN WITH DI- OR TRIPEPTIDE ANALOG CAUSING A DECREASE IN A-BETA-PEPTIDE OR AN INCREASE IN ALPHA-S-AMYLOID PRECURSOR PROTEIN | SIBIA NEUROSCIENCES INC. (US) | 2000-04-18 | — | — | US | disclosed |
| US-6017887-A | Peptide, peptide analog and amino acid analog protease inhibitors | SIBIA NEUROSCIENCES, INC. (US) | 2000-01-25 | — | — | US | disclosed |
| US-6015879-A | COMPOUNDS FOR TREATMENT OF NERVOUS SYSTEM DISORDERS INCLUDING ALZHEIMER'S DISEASE, COGNITION DEFECTS, DOWN'S SYNDROME, PARKINSON'S DISEASE, CEREBRAL HEMORRHAGE WITH AMYLOIDOSIS, DEMENTIA PUGILISTICA, AND HEAD TRAUMA | SIBIA NEUROSCIENCES, INC. (US) | 2000-01-18 | — | — | US | disclosed |
| US-5969100-A | Peptide, peptide analog and amino acid analog protease inhibitors | SIBIA NEUROSCIENCES, INC. (US) | 1999-10-19 | — | — | US | disclosed |
| US-5962419-A | NERVOUS SYSTEM DISORDERS; BRAIN DISORDERS | SIBIA NEUROSCIENCES, INC. (US) | 1999-10-05 | — | — | US | disclosed |
| US-5872101-A | Methods of treating neurodegenerative disorders using protease inhibitors | SIBIA NEUROSCIENCES, INC. (US) | 1999-02-16 | — | — | US | disclosed |
| US-5863902-A | Methods of treating neurodegenerative disorders using protease inhibitors | SIBIA NEUROSCIENCES, INC. (US) | 1999-01-26 | — | — | US | disclosed |
| US-5804560-A | MODULATES PROCESSING OF AMYLOID PRECURSOR PROTEIN | SIBIA NEUROSCIENCES, INC. (US) | 1998-09-08 | — | — | US | disclosed |
| US-5714471-A | USEFUL IN INDICATING NEURODEGENERATIVE DISORDERS CHARACTERIZED BY DEPOSITION OF CEREBRAL AMYLOID | SIBIA NEUROSCIENCES, INC. (US) | 1998-02-03 | — | — | US | disclosed |
| WO-1996020949-A1 | PEPTIDE AND PEPTIDE ANALOG PROTEASE INHIBITORS | SIBIA NEUROSCIENCES, INC. (US) | 1996-07-11 | — | — | WO | disclosed |
| WO-1996020725-A2 | PEPTIDE, PEPTIDE ANALOG AND AMINO ACID ANALOG PROTEASE INHIBITORS | SIBIA NEUROSCIENCES, INC. (US) | 1996-07-11 | — | — | WO | disclosed |