Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 12/20 | 0.45 |
| ▸ | TCF7L2 | Q9NQB0 | 12/20 | 0.45 |
| ▸ | PDE5A | O76074 | 4/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8178712 | 0.92 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DCTNNB1 | |
| SCHEMBL8170003 | 0.92 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DCTNNB1 | |
| SCHEMBL8180271 | 0.89 | CTNNB1 (0.44) | CTNNB1TCF7L2PDE5AHRH4MAPT | |
| SCHEMBL8180817 | 0.89 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DCTNNB1 | |
| SCHEMBL7019173 | 0.89 | PDE5A (0.42) | PDE4APDE4BPDE4CPDE4DCTNNB1 | |
| SCHEMBL8187337 | 0.87 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DCTNNB1 | |
| SCHEMBL8177575 | 0.87 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DCTNNB1 | |
| SCHEMBL8181251 | 0.87 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL8182382 | 0.85 | CTNNB1 (0.51) | PDE4APDE4BPDE4CPDE4DCTNNB1 | |
| SCHEMBL8180758 | 0.85 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DCTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |
| US-5948911-A | Method for inhibiting neoplastic cells and related conditions by exposure to thienopyrimidine derivatives | CELL PATHWAYS, INC. (US) | 1999-09-07 | — | — | US | disclosed |