Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 11/20 | 0.44 |
| ▸ | TCF7L2 | Q9NQB0 | 11/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8184659 | 0.92 | MAPT (0.45) | CTSBMAPTTP53HTTALDH1A1 | |
| SCHEMBL8185688 | 0.92 | CTNNB1 (0.46) | CTNNB1TCF7L2MAPTTP53HTT | |
| SCHEMBL8179215 | 0.89 | ALDH1A1 (0.47) | CTNNB1TCF7L2CTSBMAPTTP53 | |
| SCHEMBL8180789 | 0.89 | PDE4A (0.47) | CTNNB1TCF7L2MAPTPDE5AHRH4 | |
| SCHEMBL7017521 | 0.89 | HRH4 (0.41) | CTNNB1TCF7L2PDE5AHRH4 | |
| SCHEMBL8185685 | 0.89 | ALDH1A1 (0.46) | CTSBMAPTTP53HTTALDH1A1 | |
| SCHEMBL8179602 | 0.88 | CTNNB1 (0.48) | CTNNB1TCF7L2MAPTALDH1A1PTPN11 | |
| SCHEMBL8179254 | 0.88 | ICAM1 (0.48) | CTNNB1TCF7L2MAPTHTTALDH1A1 | |
| SCHEMBL8171152 | 0.87 | PDE4A (0.53) | CTNNB1TCF7L2MAPTHTTALDH1A1 | |
| SCHEMBL8184614 | 0.87 | PDE4A (0.48) | CTSBMAPTTP53HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |