SCHEMBL818161

SCHEMBL818161

CC1=C(O[Si](C)(C)C)CCCC1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL817005 0.97
SCHEMBL817354 0.95
SCHEMBL12093796 0.83
SCHEMBL5740023 0.83
SCHEMBL4891338 0.80 PREP (0.35)
SCHEMBL11344260 0.77
SCHEMBL9084404 0.75
SCHEMBL6846534 0.72
SCHEMBL12338030 0.70
SCHEMBL13607608 0.70

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7235698-B2 Enantioselective, catalytic allylation of ketones and olefins CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2007-06-26 US claimed
US-20060084820-A1 Enantioselective, catalytic allylation of ketones and olefins CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2006-04-20 US claimed
US-11718602-B2 EGFR inhibitors BLUEPRINT MEDICINES CORPORATION (US) 2023-08-08 US disclosed
US-20230098847-A1 QUATERNARY HETEROATOM CONTAINING COMPOUNDS CALIFORNIA INSTITUTE OF TECHNOLOGY 2023-03-30 US disclosed
US-11390585-B2 Quaternary heteroatom containing compounds CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2022-07-19 US disclosed
US-20220213081-A1 GEM-DISUBSTITUTED PYRROLIDINES, PIPERAZINES, AND DIAZEPANES, AND COMPOSITIONS AND METHODS OF MAKING THE SAME CALIFORNIA INSTITUTE OF TECHNOLOGY 2022-07-07 US disclosed
US-11377396-B2 Enantioselective synthesis of α-quaternary Mannich adducts by palladium-catalyzed allylic alkylation CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2022-07-05 US disclosed
EP-3274342-B1 ASYMMETRIC CATALYTIC DECARBOXYLATIVE ALKYL ALKYLATION USING LOW CATALYST CONCENTRATIONS AND A ROBUST PRECATALYST CALIFORNIA INST OF TECHN (US) 2022-05-04 EP disclosed
US-20220119377-A1 GEM-DISUBSTITUTED PYRROLIDINES, PIPERAZINES, AND DIAZEPANES, AND COMPOSITIONS AND METHODS OF MAKING THE SAME CALIFORNIA INSTITUTE OF TECHNOLOGY 2022-04-21 US disclosed
US-8809567-B2 Method for producing silylenol ethers KYOTO UNIVERSITY (JP) 2014-08-19 US disclosed
US-8809567-B2 Method for producing silylenol ethers KYOTO UNIVERSITY (JP) 2014-08-19 US disclosed
EP-2543674-A1 METHOD FOR PRODUCING SILYLENOL ETHERS Kyoto University (JP) 2013-01-09 EP disclosed
EP-2543674-A1 METHOD FOR PRODUCING SILYLENOL ETHERS Kyoto University (JP) 2013-01-09 EP disclosed
US-7906651-B2 Catalytic system of asymmetric reactions in aqueous media; react a silicon enolate and formaldehyde; catalyst obtained by mixing chiral ligands with scandium triflate JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2011-03-15 US disclosed
US-7541307-B2 Method for manufacturing an optically active hydroxymethylated compound and a catalyst therefore JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2009-06-02 US disclosed
US-20080269496-A1 Method for Producing Optically Active Hydroxymethylated Compounds JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2008-10-30 US disclosed
US-20080139835-A1 Method for Manufacturing an Optically Active Hydroxymethylated Compound and a Catalyst Therefore JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2008-06-12 US disclosed
US-20070238902-A1 Method for Performing Aldol Reaction in Water JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2007-10-11 US disclosed
US-7235698-B2 Enantioselective, catalytic allylation of ketones and olefins CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2007-06-26 US disclosed
US-7235698-B2 Enantioselective, catalytic allylation of ketones and olefins CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2007-06-26 US disclosed