Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 6/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8184826 | 0.92 | ALDH1A1 (0.41) | ALDH1A1KMT2AHSD17B10MEN1LMNA | |
| SCHEMBL8179417 | 0.91 | PDE5A (0.49) | ALDH1A1KMT2AHSD17B10MEN1LMNA | |
| SCHEMBL8185117 | 0.88 | HSD17B10 (0.50) | ALDH1A1KMT2AHSD17B10MEN1LMNA | |
| SCHEMBL8184310 | 0.87 | CNR2 (0.41) | ALDH1A1KMT2AHSD17B10MEN1LMNA | |
| SCHEMBL8170398 | 0.87 | HSD17B10 (0.47) | ALDH1A1KMT2AHSD17B10MEN1LMNA | |
| SCHEMBL8171018 | 0.87 | HSD17B10 (0.49) | ALDH1A1KMT2AHSD17B10MEN1LMNA | |
| SCHEMBL5124147 | 0.87 | MAPT (0.49) | ALDH1A1KMT2AHSD17B10MEN1LMNA | |
| SCHEMBL8177976 | 0.86 | CTNNB1 (0.44) | ALDH1A1KMT2AMEN1LMNAMAPT | |
| SCHEMBL8177771 | 0.85 | ALDH1A1 (0.48) | ALDH1A1KMT2AHSD17B10MEN1LMNA | |
| SCHEMBL8179177 | 0.85 | PDE5A (0.40) | KMT2AHSD17B10MEN1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |