Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.74 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | TTR | P02766 | 2/20 | 0.74 |
| ▸ | PIM1 | P11309 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
| ▸ | NAT1 | P18440 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1248821 | 0.85 | KMT2A (1.00) | KMT2AAKR1B1MEN1TTRPIM1 | |
| SCHEMBL1248823 | 0.85 | KMT2A (1.00) | KMT2AAKR1B1MEN1TTRPIM1 | |
| SCHEMBL8183023 | 0.81 | ALOX5 (0.48) | KMT2AAKR1B1MEN1TTRPIM1 | |
| SCHEMBL8183022 | 0.81 | ALOX5 (0.48) | KMT2AAKR1B1MEN1TTRPIM1 | |
| SCHEMBL8209418 | 0.77 | NTRK1 (0.48) | KMT2AAKR1B1MEN1TTRMAPT | |
| SCHEMBL8209417 | 0.77 | NTRK1 (0.48) | KMT2AAKR1B1MEN1TTRMAPT | |
| SCHEMBL1247506 | 0.73 | PIM1 (1.00) | KMT2AAKR1B1MEN1TTRPIM1 | |
| SCHEMBL1247507 | 0.73 | PIM1 (1.00) | KMT2AAKR1B1MEN1TTRPIM1 | |
| SCHEMBL8187527 | 0.70 | MEN1 (0.77) | KMT2AMEN1TTRALDH1A1POLB | |
| SCHEMBL8187530 | 0.70 | MEN1 (0.77) | KMT2AMEN1TTRALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018746-A1 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |