SCHEMBL818247

SCHEMBL818247

CC1=Cc2c(-c3ccc(C(C)(C)C)cc3)cccc2C1[Hf](Cl)(Cl)(C1C(C)=Cc2c(-c3ccc(C(C)(C)C)cc3)cccc21)[SiH](C)C

nearest known ligand 0.31

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
NR1H4 Q96RI1 3/20 0.31
PTAFR P25105 1/20 0.31
BRD4 O60885 1/20 0.31
CREBBP Q92793 1/20 0.31
NPC1 O15118 1/20 0.30
LMNA P02545 1/20 0.30
TP53 P04637 1/20 0.30
RAB9A P51151 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22419030 0.94 NR1H4 (0.31) NR1H4
SCHEMBL1120733 0.92
SCHEMBL7192041 0.89
SCHEMBL14142351 0.89
SCHEMBL818182 0.89 JAK2 (0.33)
SCHEMBL2233744 0.87
SCHEMBL1120750 0.87
SCHEMBL15809209 0.87
SCHEMBL817972 0.87 NR1H4 (0.32) NR1H4
SCHEMBL7197394 0.87 PTAFR (0.32) PTAFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1799726-B1 TRIALKYLALUMINUM TREATED SUPPORTS EXXONMOBIL CHEM PATENTS INC (US) 2011-07-13 EP claimed
US-7741417-B2 Preparation of polymerization catalyst activators utilizing indole-modified silica supports EXXONMOBIL CHEMICAL PATENTS INC. (US) 2010-06-22 US claimed
US-7385015-B2 Trialkylaluminum treated supports EXXONMOBIL CHEMICAL PATENTS INC. (US) 2008-06-10 US claimed
EP-1799726-A1 TRIALKYLALUMINUM TREATED SUPPORTS Exxonmobil Chemical Patents Inc. (US) 2007-06-27 EP claimed
US-7220695-B2 Supported activator EXXONMOBIL CHEMICAL PATENTS INC. (US) 2007-05-22 US claimed
US-20070055028-A1 Preparation of polymerization catalyst activators utilizing indole-modified silica supports EXXONMOBIL CHEMICAL PATENTS INC. 2007-03-08 US claimed
WO-2006044058-A1 TRIALKYLALUMINUM TREATED SUPPORTS EXXONMOBIL CHEMICAL PATENTS INC. (US) 2006-04-27 WO claimed
US-20060079394-A1 Trialkylaluminum treated supports EXXONMOBIL CHEMICAL PATENTS INC. 2006-04-13 US claimed
US-20050148743-A1 polymerization catalyst systems comprising an ion-exchange layered silicate, an organoaluminum compound, and a heterocyclic compound EXXONMOBIL CHEMICAL PATENTS INC. 2005-07-07 US claimed
EP-1053263-B1 CATALYST SYSTEM BASELL POLYOLEFINE GMBH (DE) 2003-10-01 EP claimed
US-6482902-B1 Catalyst system TARGOR GMBH (DE) 2002-11-19 US claimed
US-6350830-B1 SUPPORTED POLYMERIZATION CATALYSTS TAGOR GMBH (DE) 2002-02-26 US claimed
EP-2760958-B1 SYSTEMS, METHODS AND COMPOSITIONS FOR PRODUCTION OF TIE-LAYER ADHESIVES EQUISTAR CHEM LP (US) 2020-08-12 EP disclosed
US-10676547-B2 Aluminum alkyls with pendant olefins on clays EXXONMOBIL CHEMICAL PATENTS INC. (US) 2020-06-09 US disclosed
EP-2673315-B1 POLYETHYLENE FILMS EQUISTAR CHEM LP (US) 2019-03-20 EP disclosed
EP-2064248-B1 PREPARATION OF POLYMERIZATION CATALYST ACTIVATORS UTILIZING INDOLE-MODIFIED SILICA SUPPORTS EXXONMOBIL CHEMICAL PATENTS INC (US) 2018-10-10 EP disclosed
US-20030008984-A1 Novel catalyst system and the use thereof BASELL POLYOLEFINE GMBH (DE) 2003-01-09 US disclosed
US-6500908-B1 ORGANOBORON-ALUMINUM COMPOUND, METALLOCENE, COCATALYTICALLY ACTIVE COMPOUND; BIS(DIMETHYLALUMINOXY)PENTAFLUOROPHENYLBORANE; OLEFIN POLYMERIZATION CATALYST BASELL POLYOLEFINE GMBH (DE) 2002-12-31 US disclosed
US-6482902-B1 Catalyst system TARGOR GMBH (DE) 2002-11-19 US disclosed
US-6350830-B1 SUPPORTED POLYMERIZATION CATALYSTS TAGOR GMBH (DE) 2002-02-26 US disclosed