SCHEMBL818182

SCHEMBL818182

CC1=Cc2c(-c3ccc(C(F)(F)F)cc3)cccc2C1[Hf](Cl)(Cl)(C1C(C)=Cc2c(-c3ccc(C(F)(F)F)cc3)cccc21)[SiH](C)C

nearest known ligand 0.33

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
JAK2 O60674 1/20 0.33
ENPP1 P22413 1/20 0.31
DRD2 P14416 1/20 0.31
KIF11 P52732 1/20 0.30
CYP11B1 P15538 1/20 0.30
CYP11B2 P19099 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL818247 0.89 NR1H4 (0.31)
SCHEMBL2233744 0.86
SCHEMBL217396 0.85 HTR2B (0.31)
SCHEMBL22419030 0.84 NR1H4 (0.31)
SCHEMBL8465335 0.83 ENPP1 (0.33) JAK2ENPP1DRD2KIF11
SCHEMBL7182157 0.82
SCHEMBL1120733 0.82
SCHEMBL14142351 0.81
SCHEMBL817868 0.80
SCHEMBL7192041 0.79

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2760958-B1 SYSTEMS, METHODS AND COMPOSITIONS FOR PRODUCTION OF TIE-LAYER ADHESIVES EQUISTAR CHEM LP (US) 2020-08-12 EP disclosed
EP-2673315-B1 POLYETHYLENE FILMS EQUISTAR CHEM LP (US) 2019-03-20 EP disclosed
EP-1943281-B1 HYBRID CATALYST SYSTEMS SUPPORTED ON MAGNESIUM HALIDE BASELL POLYOLEFINE GMBH (DE) 2017-09-20 EP disclosed
US-9676971-B2 Systems, methods and compositions for production of tie-layer adhesives EQUISTAR CHEMICALS, LP (US) 2017-06-13 US disclosed
US-20160222257-A1 SYSTEMS, METHODS AND COMPOSITIONS FOR PRODUCTION OF TIE-LAYER ADHESIVES EQUISTAR CHEMICALS, LP (US) 2016-08-04 US disclosed
US-9321945-B2 Systems, methods and compositions for production of tie-layer adhesives EQUISTAR CHEMICALS, LP (US) 2016-04-26 US disclosed
US-9029478-B2 High clarity polyethylene films EQUISTAR CHEMICALS, LP (US) 2015-05-12 US disclosed
EP-2114567-B1 IRON COMPLEXES AND THEIR USE IN POLYMERIZATION PROCESSES BASELL POLYOLEFINE GMBH (DE) 2015-04-15 EP disclosed
US-8865834-B2 Adhesive polymer composition BASELL POLYOLEFINE GMBH (DE) 2014-10-21 US disclosed
EP-2760958-A1 SYSTEMS, METHODS AND COMPOSITIONS FOR PRODUCTION OF TIE-LAYER ADHESIVES Equistar Chemicals, LP (US) 2014-08-06 EP disclosed
US-20070213205-A1 Polyethylene and Catalyst Composition for its Preparation BASELL POLYOLEFINE GMBH (DE) 2007-09-13 US disclosed
WO-2007042252-A1 HYBRID CATALYST SYSTEMS SUPPORTED ON MAGNESIUM HALIDE BASELL POLYOLEFINE GMBH (DE) 2007-04-19 WO disclosed
EP-1753791-A1 POLYETHYLENE FOR INJECTION MOLDINGS Basell Polyolefine GmbH (DE) 2007-02-21 EP disclosed
EP-1753794-A1 POLYETHYLENE AND CATALYST COMPOSITION FOR ITS PREPARATION Basell Polyolefine GmbH (DE) 2007-02-21 EP disclosed
EP-1740623-A1 POLYETHYLENE AND CATALYST COMPOSITION FOR ITS PREPARATION Basell Polyolefine GmbH (DE) 2007-01-10 EP disclosed
WO-2005103100-A1 POLYETHYLENE AND CATALYST COMPOSITION FOR ITS PREPARATION BASELL POLYOLEFINE GMBH (DE) 2005-11-03 WO disclosed
WO-2005103096-A1 POLYETHYLENE FOR INJECTION MOLDINGS BASELL POLYOLEFINE GMBH (DE) 2005-11-03 WO disclosed
WO-2005103095-A1 POLYETHYLENE AND CATALYST COMPOSITION FOR ITS PREPARATION BASELL POLYOLEFINE GMBH (DE) 2005-11-03 WO disclosed
EP-0653433-B1 Novel transition metal compound, olefin polymerization catalyst component comprising the transition metal compound, olefin polymerization catalyst comprising the olefin polymerization catalyst component, and process for olefin polymerization MITSUI CHEMICALS INC (JP) 1999-01-13 EP disclosed
EP-0653433-A1 Novel transition metal compound, olefin polymerization catalyst component comprising the transition metal compound, olefin polymerization catalyst comprising the olefin polymerization catalyst component, and process for olefin polymerization MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1995-05-17 EP disclosed