Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.68 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.41 |
| ▸ | TTR | P02766 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | NAT1 | P18440 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.36 |
| ▸ | TUBB | P07437 | 2/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8182711 | 1.00 | GSK3B (0.68) | GSK3BCYP2A6PIM1PIM2PIM3 | |
| SCHEMBL8180533 | 0.95 | GSK3B (0.71) | GSK3BCYP2A6PIM1PIM2PIM3 | |
| SCHEMBL8167446 | 0.82 | GSK3B (0.54) | GSK3BCYP2A6PIM1MEN1KMT2A | |
| SCHEMBL8182589 | 0.75 | GSK3B (0.43) | GSK3BCYP2A6TUBB4ATUBBTUBA3C | |
| SCHEMBL8181630 | 0.72 | PIM1 (0.54) | GSK3BPIM1PIM2PIM3AKR1B1 | |
| SCHEMBL8187128 | 0.72 | PIM1 (0.53) | GSK3BPIM1PIM2PIM3AKR1B1 | |
| SCHEMBL8181632 | 0.72 | PIM1 (0.54) | GSK3BPIM1PIM2PIM3AKR1B1 | |
| SCHEMBL22409598 | 0.71 | AKR1B1 (0.51) | GSK3BPIM1PIM2PIM3AKR1B1 | |
| SCHEMBL22423776 | 0.71 | AKR1B1 (0.51) | GSK3BPIM1PIM2PIM3AKR1B1 | |
| SCHEMBL6002690 | 0.70 | CYP2A6 (0.53) | GSK3BCYP2A6MEN1KMT2ATUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018746-A1 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |