Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.71 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 2/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 2/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | NAT1 | P18440 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8182711 | 0.95 | GSK3B (0.68) | GSK3BCYP2A6PIM1PIM2PIM3 | |
| SCHEMBL8182708 | 0.95 | GSK3B (0.68) | GSK3BCYP2A6PIM1PIM2PIM3 | |
| SCHEMBL8167446 | 0.87 | GSK3B (0.54) | GSK3BCYP2A6PIM1MEN1KMT2A | |
| SCHEMBL8187128 | 0.77 | PIM1 (0.53) | GSK3BPIM1PIM2PIM3TTR | |
| SCHEMBL22409598 | 0.76 | AKR1B1 (0.51) | GSK3BPIM1PIM2PIM3TTR | |
| SCHEMBL22423776 | 0.76 | AKR1B1 (0.51) | GSK3BPIM1PIM2PIM3TTR | |
| SCHEMBL13846678 | 0.74 | PIM1 (0.67) | GSK3BPIM1PIM2PIM3AKR1B1 | |
| SCHEMBL22423780 | 0.74 | PIM1 (0.67) | GSK3BPIM1PIM2PIM3AKR1B1 | |
| SCHEMBL22409611 | 0.74 | PIM1 (0.67) | GSK3BPIM1PIM2PIM3AKR1B1 | |
| SCHEMBL8183740 | 0.73 | PIM1 (0.55) | GSK3BCYP2A6PIM1PIM2PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000018746-A1 | THIAZOLIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS | ROCHE DIAGNOSTICS GMBH (DE) | 2000-04-06 | — | — | WO | disclosed |