Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8171096 | 0.91 | RHOA (0.43) | MAPTTDP1KMT2AALDH1A1JAK2 | |
| SCHEMBL7013520 | 0.90 | JAK2 (0.39) | MAPTKMT2ARAB9AJAK2JAK3 | |
| SCHEMBL8180129 | 0.88 | MAPT (0.45) | MAPTTDP1TP53HTTCTSB | |
| SCHEMBL8185660 | 0.87 | MAPT (0.46) | MAPTKMT2ARAB9AIGF1RALDH1A1 | |
| SCHEMBL7014536 | 0.87 | JAK2 (0.40) | MAPTKMT2AALDH1A1JAK2JAK3 | |
| SCHEMBL8179116 | 0.87 | MAPT (0.44) | MAPTTDP1TP53HTTCTSB | |
| SCHEMBL8179525 | 0.86 | PSMD14 (0.44) | MAPTTDP1TP53HTTCTSB | |
| SCHEMBL8181603 | 0.86 | MAPT (0.46) | MAPTTDP1TP53HTTCTSB | |
| SCHEMBL8179070 | 0.85 | MAPT (0.45) | MAPTTDP1TP53HTTCTSB | |
| SCHEMBL8184659 | 0.85 | MAPT (0.45) | MAPTTDP1TP53HTTCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |