Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.49 |
| ▸ | PDE5A | O76074 | 5/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | PDE1A | P54750 | 1/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 10/20 | 0.40 |
| ▸ | TCF7L2 | Q9NQB0 | 10/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8180295 | 0.93 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL8170609 | 0.91 | PDE5A (0.52) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL8177714 | 0.90 | ALDH1A1 (0.50) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL7018489 | 0.90 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL8170901 | 0.89 | EPHX2 (0.46) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL8171136 | 0.89 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL8172354 | 0.89 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL8185560 | 0.88 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL8178158 | 0.88 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL8171364 | 0.86 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |