Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 7/20 | 0.37 |
| ▸ | HTR6 | P50406 | 4/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2751652 | 0.92 | BRD4 (0.35) | BRD4HTR6PTPN11PDPK1JAK1 | |
| SCHEMBL8191891 | 0.91 | BRD4 (0.36) | BRD4HTR6PTPN11PDPK1JAK1 | |
| SCHEMBL8184050 | 0.88 | PDPK1 (0.41) | BRD4HTR6PTPN11PDPK1 | |
| SCHEMBL2752845 | 0.85 | BRD4 (0.35) | BRD4HTR6PTPN11PDPK1JAK1 | |
| SCHEMBL2753762 | 0.84 | ACVR1 (0.41) | BRD4HTR6 | |
| SCHEMBL2753766 | 0.84 | ACVR1 (0.41) | BRD4HTR6 | |
| SCHEMBL8183942 | 0.81 | BRD4 (0.35) | BRD4HTR6TPSAB1 | |
| SCHEMBL2753717 | 0.80 | HTR6 (0.39) | BRD4HTR6PTPN11PDPK1CA12 | |
| SCHEMBL2753841 | 0.80 | PDPK1 (0.42) | BRD4HTR6PTPN11PDPK1 | |
| SCHEMBL2753753 | 0.78 | PDPK1 (0.43) | BRD4HTR6PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008095944-A1 | 7-AZAINDOLE DERIVATIVES AND THEIR USE IN THE INHIBITION OF C-JUN N-TERMINAL KINASE | EISAI R&D MANAGEMENT CO. LTD. (JP) | 2008-08-14 | — | — | WO | disclosed |