Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 13/20 | 0.59 |
| ▸ | CTSS | P25774 | 6/20 | 0.55 |
| ▸ | CTSL | P07711 | 6/20 | 0.55 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.53 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.53 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.53 |
| ▸ | CTSB | P07858 | 4/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7810119 | 0.83 | CTSK (0.53) | CTSKCTSSCTSLCTSB | |
| SCHEMBL8192697 | 0.82 | CTSK (0.56) | CTSKCTSSCTSLPSMB1PSMB5 | |
| SCHEMBL8185941 | 0.82 | CTSK (0.56) | CTSKCTSSCTSLPSMB1PSMB5 | |
| SCHEMBL8177444 | 0.82 | CTSK (0.56) | CTSKCTSSCTSLPSMB1PSMB5 | |
| SCHEMBL7809206 | 0.82 | CTSK (0.54) | CTSKCTSSCTSLCTSB | |
| SCHEMBL14911685 | 0.79 | CTSK (0.62) | CTSKCTSSCTSLCTSB | |
| SCHEMBL27543998 | 0.77 | CTSK (0.67) | CTSKCTSSCTSLPSMB1PSMB5 | |
| SCHEMBL7141423 | 0.77 | CTSK (0.70) | CTSKCTSSCTSLPSMB1PSMB5 | |
| SCHEMBL25406813 | 0.77 | CTSK (0.77) | CTSKCTSSCTSLCTSB | |
| SCHEMBL8823918 | 0.77 | CTSK (0.77) | CTSKCTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6051684-A | CONTACTING A COMPOSITION CONTAINING AMYLOID PRECURSOR PROTEIN WITH DI- OR TRIPEPTIDE ANALOG CAUSING A DECREASE IN A-BETA-PEPTIDE OR AN INCREASE IN ALPHA-S-AMYLOID PRECURSOR PROTEIN | SIBIA NEUROSCIENCES INC. (US) | 2000-04-18 | — | — | US | claimed |
| WO-1996020949-A1 | PEPTIDE AND PEPTIDE ANALOG PROTEASE INHIBITORS | SIBIA NEUROSCIENCES, INC. (US) | 1996-07-11 | — | — | WO | claimed |
| US-6153171-A | Methods for identifying compounds effective for treating neurodegenerative disorders and for monitoring the therapeutic intervention therefor | SIBIA NEUROSCIENCES, INC. (US) | 2000-11-28 | — | — | US | disclosed |
| US-6051684-A | CONTACTING A COMPOSITION CONTAINING AMYLOID PRECURSOR PROTEIN WITH DI- OR TRIPEPTIDE ANALOG CAUSING A DECREASE IN A-BETA-PEPTIDE OR AN INCREASE IN ALPHA-S-AMYLOID PRECURSOR PROTEIN | SIBIA NEUROSCIENCES INC. (US) | 2000-04-18 | — | — | US | disclosed |
| US-6015879-A | COMPOUNDS FOR TREATMENT OF NERVOUS SYSTEM DISORDERS INCLUDING ALZHEIMER'S DISEASE, COGNITION DEFECTS, DOWN'S SYNDROME, PARKINSON'S DISEASE, CEREBRAL HEMORRHAGE WITH AMYLOIDOSIS, DEMENTIA PUGILISTICA, AND HEAD TRAUMA | SIBIA NEUROSCIENCES, INC. (US) | 2000-01-18 | — | — | US | disclosed |
| US-5962419-A | NERVOUS SYSTEM DISORDERS; BRAIN DISORDERS | SIBIA NEUROSCIENCES, INC. (US) | 1999-10-05 | — | — | US | disclosed |
| US-5804560-A | MODULATES PROCESSING OF AMYLOID PRECURSOR PROTEIN | SIBIA NEUROSCIENCES, INC. (US) | 1998-09-08 | — | — | US | disclosed |
| US-5714471-A | USEFUL IN INDICATING NEURODEGENERATIVE DISORDERS CHARACTERIZED BY DEPOSITION OF CEREBRAL AMYLOID | SIBIA NEUROSCIENCES, INC. (US) | 1998-02-03 | — | — | US | disclosed |
| EP-0800528-A1 | PEPTIDE AND PEPTIDE ANALOG PROTEASE INHIBITORS | Sibia Neurosciences, Inc. (US) | 1997-10-15 | — | — | EP | disclosed |
| WO-1996020949-A1 | PEPTIDE AND PEPTIDE ANALOG PROTEASE INHIBITORS | SIBIA NEUROSCIENCES, INC. (US) | 1996-07-11 | — | — | WO | disclosed |