Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8188941 | 0.92 | ACACB (0.39) | ACACBALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL8184731 | 0.86 | ACACB (0.38) | ACACBALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL8183622 | 0.85 | ACACB (0.37) | ACACBALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL8180999 | 0.85 | SYK (0.39) | ACACBALDH1A1LMNAGAAKDM4E | |
| SCHEMBL8189038 | 0.85 | PGK1 (0.38) | ACACBALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL8179729 | 0.84 | ACACB (0.35) | ACACBALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL8195154 | 0.84 | CYP3A4 (0.37) | ACACBALDH1A1MAPTTSHRKDM4E | |
| SCHEMBL8175218 | 0.84 | ACACB (0.36) | ACACBALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL8184729 | 0.84 | CFTR (0.35) | ACACBALDH1A1MAPTTSHRHTT | |
| SCHEMBL8179960 | 0.84 | TNF (0.37) | ACACBALDH1A1SMN1; SMN2GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008077557-A1 | 8-ETHINYLXANTHINE DERIVATIVES AS SELECTIVE A2A RECEPTOR ANTAGONISTS | SCHWARZ PHARMA AG (DE) | 2008-07-03 | — | — | WO | disclosed |