Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | PDE5A | O76074 | 1/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.46 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.46 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.44 |
| ▸ | SELE | P16581 | 1/20 | 0.44 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8179317 | 0.91 | PRKCI (0.52) | PRKCIKDM4EALDH1A1HSD17B10PDE5A | |
| SCHEMBL8184738 | 0.90 | ICAM1 (0.56) | PRKCIKDM4EALDH1A1HSD17B10PDE5A | |
| SCHEMBL8169995 | 0.88 | PDE5A (0.50) | PRKCIKDM4EALDH1A1HSD17B10PDE5A | |
| SCHEMBL5120106 | 0.87 | PRKCI (0.73) | PRKCIKDM4EALDH1A1HSD17B10PDE5A | |
| SCHEMBL8184884 | 0.86 | PDE5A (0.50) | PRKCIKDM4EPDE5ACSNK2A1SLC6A3 | |
| SCHEMBL8181651 | 0.85 | PRKCI (0.48) | PRKCIKDM4EALDH1A1HSD17B10PDE5A | |
| SCHEMBL8185136 | 0.85 | PRKCI (0.48) | PRKCIKDM4EALDH1A1HSD17B10P2RY12 | |
| SCHEMBL8183227 | 0.85 | PDE5A (0.47) | PRKCIKDM4EALDH1A1PDE5ACSNK2A1 | |
| SCHEMBL8185712 | 0.82 | PDE5A (0.47) | KDM4EPDE5ACSNK2A1SLC6A3CSNK2A2 | |
| SCHEMBL5122806 | 0.82 | GBA1 (0.64) | PRKCIALDH1A1HSD17B10PDE5AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |
| US-5948911-A | Method for inhibiting neoplastic cells and related conditions by exposure to thienopyrimidine derivatives | CELL PATHWAYS, INC. (US) | 1999-09-07 | — | — | US | disclosed |